Melanocortin-2 receptor accessory protein 2 (MRAP2) Recombinant Protein | MRAP2 recombinant protein

Recombinant Human Melanocortin-2 receptor accessory protein 2 (MRAP2) , partial

• Gene Names: MRAP2; C6orf117; bA51G5.2
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Melanocortin-2 receptor accessory protein 2 (MRAP2); Recombinant Human Melanocortin-2 receptor accessory protein 2 (MRAP2); partial; MRAP2 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 205

• Species: Homo sapiens (Human)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 1083260032
• NCBI GeneID: 112609
• NCBI Accession #: NP_001333470.1
• NCBI GenBank Nucleotide #: NM_001346541.1
• UniProt Accession #: Q96G30; Q8IXM9; Q8N2D1; A8K9M1
• Molecular Weight: 23,548 Da
• NCBI Official Full Name: melanocortin-2 receptor accessory protein 2 isoform 2
• NCBI Official Synonym Full Names: melanocortin 2 receptor accessory protein 2
• NCBI Official Symbol: MRAP2
• NCBI Official Synonym Symbols: C6orf117; bA51G5.2
• NCBI Protein Information: melanocortin-2 receptor accessory protein 2
• UniProt Protein Name: Melanocortin-2 receptor accessory protein 2
• Protein Family: Melanocortin-2 receptor accessory protein
• UniProt Gene Name: MRAP2
• UniProt Synonym Gene Names: C6orf117; MC2R accessory protein 2

NCBI Description

This gene encodes a protein that modulates melanocortin receptor signaling. The encoded protein has been shown to interact with all known melanocortin receptors and may regulate both receptor trafficking and activation in response to ligands. Mice lacking a functional copy of this gene exhibit severe obesity and a mutation in this gene may be associated with severe obesity in human patients. [provided by RefSeq, Oct 2016]

Uniprot Description

Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP (). May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo.