Western Blot (WB)
(Western Blot analysis of MRAP2 expression in transfected 293T cell line by MRAP2 polyclonal antibody. Lane 1: C6orf117 transfected lysate (23.5kD). Lane 2: Non-transfected lysate.)
Mouse anti-Human MRAP2 Polyclonal Antibody | anti-MRAP2 antibody
MRAP2 (Melanocortin-2 Receptor Accessory Protein 2, C6orf117, RP11-51G5.2)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Western Blot (WB)
(Western Blot analysis of MRAP2 expression in transfected 293T cell line by MRAP2 polyclonal antibody. Lane 1: C6orf117 transfected lysate (23.5kD). Lane 2: Non-transfected lysate.)
Western Blot (WB)
(Western Blot analysis of MRAP2 expression in transfected 293T cell line by MRAP2 polyclonal antibody. Lane 1: C6orf117 transfected lysate (23.5kD). Lane 2: Non-transfected lysate.)
NCBI and Uniprot Product Information
Uniprot Description
Function: Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP
By similarity. May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo. Ref.5 Ref.6
Subunit structure: Homodimer and heterodimer. Forms antiparallel homodimers and heterodimers with MRAP. Interacts with MC1R, MC2R, MC3R, MC4R and MC5R. Ref.5 Ref.6
Subcellular location: Cell membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. Note: The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context (Ref.6). Ref.5
Tissue specificity: Expressed in the adrenal gland and brain. Not expressed in other tissues. Ref.5
Involvement in disease: May be associated with obesity, a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. Additional evidences are however required (Ref.7).
Sequence similarities: Belongs to the MRAP family.
Research Articles on MRAP2
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Product Notes
The MRAP2 mrap2 (Catalog #AAA645692) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The MRAP2 (Melanocortin-2 Receptor Accessory Protein 2, C6orf117, RP11-51G5.2) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MRAP2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Researchers should empirically determine the suitability of the MRAP2 mrap2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MSAQRLISNR TSQQSASNSD YTWEYEYYEI GPVSFEGLKA HKYSIVIGFW VGLAVFVIFM FFVLTLLTKT GAPHQDNAES SEKRFRMNSF VSDFGRPLEP DKVFSRQGNE ESRSLFHCYI NEVERLDRAK ACHQTTALDS DVQLQEAIRS SGQPEEELNR LMKFDIPNFV NTDQNYFGED DLLISEPPIV LETKPLSQTS HKDLD. It is sometimes possible for the material contained within the vial of "MRAP2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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