Mouse Tumor Necrosis Factor Ligand Superfamily, Member 12 (TNFSF12) RTU ELISA Kit | TNFSF12 rtu elisa kit

Mouse Tumor Necrosis Factor Ligand Superfamily, Member 12 (TNFSF12) ELISA Kit

Cat. Num. AAA4503903

• Gene Names: MUC16; CA125
• Reactivity: Mouse
• Synonyms: Tumor Necrosis Factor Ligand Superfamily; Member 12 (TNFSF12); Mouse Tumor Necrosis Factor Ligand Superfamily; Member 12 (TNFSF12) ELISA Kit; APO3L; DR3LG; TWEAK; APO3 ligand; TNF-related weak inducer of apoptosis; TNFSF12 rtu elisa kit

• Reactivity: Mouse
• Sequence Length: 14507

• Assay Type: Sandwich
• Samples: Serum, Plasma, Tissue Homogenates or Other Biological Fluids.
• Detection Range: 78.1-5000pg/mL
• Sensitivity: 31.6pg/mL
• RTU ELISA Kit's Advantage: The Ready-To-Use (RTU) Kits require fewer steps in setup and take less time to run. Detection Solutions are pre-diluted and total incubation time is shorter than many other ELISA Kits.
• Preparation and Storage: For unopened kits: All the reagents should be kept at 4 degree C upon receipt.; For opened kits: Once the kit is opened, the remaining reagents still need to be stored according to the above storage conditions. In addition, return the unused wells to the foil pouch containing the desiccant pack and reseal along entire edge of zip-seal.

NCBI and Uniprot Product Information

• NCBI GI #: 83367077
• NCBI GeneID: 94025
• NCBI Accession #: NP_078966.2
• NCBI GenBank Nucleotide #: NP_078966.2
• UniProt Accession #: Q8WXI7
• NCBI Official Full Name: mucin-16
• NCBI Official Synonym Full Names: mucin 16, cell surface associated
• NCBI Official Symbol: MUC16
• NCBI Official Synonym Symbols: CA125
• NCBI Protein Information: mucin-16
• UniProt Protein Name: Mucin-16
• Protein Family: Tumor necrosis factor ligand superfamily
• UniProt Gene Name: MUC16
• UniProt Synonym Gene Names: CA125; MUC-16; CA-125
• UniProt Entry Name: MUC16_HUMAN

NCBI Description

This gene encodes a protein that is a member of the mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered mucin that contains an extracellular domain at its amino terminus, a large tandem repeat domain, and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated, while the repeat region contains 156 amino acid repeats unit that are rich in serines, threonines, and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules, leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain, and there is a potential cleavage site found near an SEA module close to the transmembrane domain. This protein is thought to play a role in forming a barrier, protecting epithelial cells from pathogens. Products of this gene have been used as a marker for different cancers, with higher expression levels associated with poorer outcomes. [provided by RefSeq, May 2017]

Uniprot Description

MUC16: Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.

Protein type: Membrane protein, integral; Cell adhesion; Membrane protein, peripheral

Chromosomal Location of Human Ortholog: 19p13.2

Cellular Component: extracellular space; extrinsic to membrane; Golgi lumen; integral to membrane; plasma membrane; vesicle

Molecular Function: protein binding

Biological Process: protein amino acid O-linked glycosylation; cellular protein metabolic process; O-glycan processing; cell adhesion; post-translational protein modification