Mouse Sortilin 1 (SORT1) RTU ELISA Kit | SORT1 rtu elisa kit

Mouse Sortilin 1 (SORT1) ELISA Kit

Cat. Num. AAA4502594

• Gene Names: Sort1; Ntr3; Ntsr3; AI852375; 2900053A11Rik
• Reactivity: Mouse
• Synonyms: Sortilin 1 (SORT1); Mouse Sortilin 1 (SORT1) ELISA Kit; NT3; Gp95; NTR3; 100 kDa NT receptor; Glycoprotein 95; Neurotensin receptor 3; SORT1 rtu elisa kit

• Reactivity: Mouse
• Sequence Length: 858

• Assay Type: Sandwich
• Samples: Serum, Plasma, Tissue Homogenates or Other Biological Fluids.
• Detection Range: 0.156-10ng/mL
• Sensitivity: 0.066ng/mL
• RTU ELISA Kit's Advantage: The Ready-To-Use (RTU) Kits require fewer steps in setup and take less time to run. Detection Solutions are pre-diluted and total incubation time is shorter than many other ELISA Kits.
• Preparation and Storage: For unopened kits: All the reagents should be kept at 4 degree C upon receipt.; For opened kits: Once the kit is opened, the remaining reagents still need to be stored according to the above storage conditions. In addition, return the unused wells to the foil pouch containing the desiccant pack and reseal along entire edge of zip-seal.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for SORT1 rtu elisa kit

Test Principle: The microtiter plate provided in this kit has been pre-coated with an antibody specific to SORT1. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation specific to SORT1. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain SORT1, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of SORT1 in the samples is then determined by comparing the O.D. of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 409264681
• NCBI GeneID: 20661
• NCBI Accession #: NP_001258528.1
• NCBI GenBank Nucleotide #: NM_001271599.1
• UniProt Accession #: Q6PHU5; Q3UHE2; Q8K043; Q9QXW6; A2AEE8
• Molecular Weight: 94,813 Da
• NCBI Official Full Name: sortilin isoform 1
• NCBI Official Synonym Full Names: sortilin 1
• NCBI Official Symbol: Sort1
• NCBI Official Synonym Symbols: Ntr3; Ntsr3; AI852375; 2900053A11Rik
• NCBI Protein Information: sortilin
• UniProt Protein Name: Sortilin
• Protein Family: Sortilin
• UniProt Gene Name: Sort1
• UniProt Synonym Gene Names: NTR3; mNTR3

Uniprot Description

Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.