Mouse C-Ros Oncogene 1, Receptor Tyrosine Kinase (ROS1) RTU ELISA Kit | ROS1 rtu elisa kit

Mouse C-Ros Oncogene 1, Receptor Tyrosine Kinase (ROS1) ELISA Kit

Cat. Num. AAA4503739

• Gene Names: Ros1; Ros-1; c-ros
• Reactivity: Mouse
• Synonyms: C-Ros Oncogene 1; Receptor Tyrosine Kinase (ROS1); Mouse C-Ros Oncogene 1; Receptor Tyrosine Kinase (ROS1) ELISA Kit; MCF3; ROS; c-Ros-1; v-Ros Avian UR2 Sarcoma Virus Oncogene Homolog 1; Proto-oncogene tyrosine-protein kinase ROS; Receptor tyrosine kinase c-ros oncogene 1; ROS1 rtu elisa kit

• Reactivity: Mouse
• Sequence Length: 2340

• Assay Type: Sandwich
• Samples: Serum, Plasma, Tissue Homogenates or Other Biological Fluids.
• Detection Range: 78.1-5000pg/mL
• Sensitivity: 33pg/mL
• RTU ELISA Kit's Advantage: The Ready-To-Use (RTU) Kits require fewer steps in setup and take less time to run. Detection Solutions are pre-diluted and total incubation time is shorter than many other ELISA Kits.
• Preparation and Storage: For unopened kits: All the reagents should be kept at 4 degree C upon receipt.; For opened kits: Once the kit is opened, the remaining reagents still need to be stored according to the above storage conditions. In addition, return the unused wells to the foil pouch containing the desiccant pack and reseal along entire edge of zip-seal.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for ROS1 rtu elisa kit

Test Principle: The microtiter plate provided in this kit has been pre-coated with an antibody specific to ROS1. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation specific to ROS1. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain ROS1, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of ROS1 in the samples is then determined by comparing the O.D. of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 114326510
• NCBI GeneID: 19886
• NCBI Accession #: NP_035412.2
• NCBI GenBank Nucleotide #: NM_011282.2
• UniProt Accession #: Q78DX7; Q60705
• Molecular Weight: 261,967 Da
• NCBI Official Full Name: proto-oncogene tyrosine-protein kinase ROS
• NCBI Official Synonym Full Names: Ros1 proto-oncogene
• NCBI Official Symbol: Ros1
• NCBI Official Synonym Symbols: Ros-1; c-ros
• NCBI Protein Information: proto-oncogene tyrosine-protein kinase ROS
• UniProt Protein Name: Proto-oncogene tyrosine-protein kinase ROS
• Protein Family: Protein
• UniProt Gene Name: Ros1
• UniProt Synonym Gene Names: Ros; Ros-1

Uniprot Description

Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1, and PLCG2.