Mouse anti-Human TIGIT Antibody | anti-TIGIT antibody

Anti-TIGIT Purified (with Antibiotics)

Cat. Num. AAA666935

• Gene Names: TIGIT; VSIG9; VSTM3; WUCAM
• Reactivity: Human
• Synonyms: TIGIT; Anti-TIGIT Purified (with Antibiotics); Anti-Human TIGIT; T cell immunoreceptor with Ig and ITIM domains; anti-TIGIT antibody

• Host: Mouse
• Reactivity: Human
• Isotype: IgG1k
• Clone Number: ANCTG6/10A6
• Specificity: Antibody ANCTG6 binds to receptors on a sub set of human peripheral blood lymphoid cells, as well as to recombinant TIGIT in EIA.
• Sequence Length: 244

• Immunogen: Recombinant human TIGIT

Related Product Information for anti-TIGIT antibody

Human TIGIT (T cell immunoreceptor with Ig and ITIM domains) is a co inhibitory receptor expressed by activated T cells, memory T cells, Treg cells and NK cells. It binds ot CD155(PVR) and less avidly to CD112(PVRL2).

Product Categories/Family for anti-TIGIT antibody

Antibodies; Conjugates

References

1) Dougall WC, AC Anderson, et al. (2017) Immunol Rev 276(1): 112-120. doi: 10.1111/imr.12518 PMID: 28258695

NCBI and Uniprot Product Information

• NCBI GI #: 256600228
• NCBI GeneID: 201633
• NCBI Accession #: NP_776160.2
• NCBI GenBank Nucleotide #: NM_173799.4
• UniProt Accession #: Q495A1; Q495A3; Q5JPD8; Q6MZS2; Q8N877
• Molecular Weight: 18,432 Da
• NCBI Official Full Name: T-cell immunoreceptor with Ig and ITIM domains
• NCBI Official Synonym Full Names: T cell immunoreceptor with Ig and ITIM domains
• NCBI Official Symbol: TIGIT
• NCBI Official Synonym Symbols: VSIG9; VSTM3; WUCAM
• NCBI Protein Information: T-cell immunoreceptor with Ig and ITIM domains
• UniProt Protein Name: T-cell immunoreceptor with Ig and ITIM domains
• Protein Family: T-cell immunoreceptor with Ig and ITIM domains
• UniProt Gene Name: TIGIT
• UniProt Synonym Gene Names: VSIG9; VSTM3

NCBI Description

This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses.[provided by RefSeq, Sep 2009]

Uniprot Description

Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.