Mouse anti-Human HLA-DR1 Antibody | anti-HLA-DR1 antibody

Anti-HLA-DR1 (empty) Purified

Cat. Num. AAA1801184

• Reactivity: Human
• Applications: Western Blot, Flow Cytometry, Functional Assay, ELISA
• Purity: Purified by Protein-A Affinity Chromatography
• Synonyms: HLA-DR1; Anti-HLA-DR1 (empty) Purified; HLA-DR1 (empty); anti-HLA-DR1 antibody

• Host: Mouse
• Reactivity: Human
• Isotype: IgG2b
• Clone Number: MEM-267
• Specificity: The antibody MEM-267 specifically binds extracellularly to the empty but not peptide-loaded form of HLA-DR1. DR is the isotypes of human MHC Class II molecules expressed on antigen-presenting cells (APC; dendritic cells, B lymphocytes, monocytes, macrophages).
• Purity/Purification: Purified by Protein-A Affinity Chromatography
• Form/Format: Phosphate buffered saline (PBS) solution with 15 mM sodium azide
• Concentration: 1 mg/ml (varies by lot)

• Applicable Applications for anti-HLA-DR1 antibody: Western Blot (WB), Flow Cytometry (FC/FACS), ELISA (EIA)
• Immunogen: Purified, insoluble DR1 beta chain (DRB1*0101) expressed in E. coli inclusion bodies.
• Preparation and Storage: Store at 2-8 degree C.

Western Blot (WB)

(Western blotting analysis of HLA-DR1 in Raji (A) and Jurkat (B) cell lines using MEM-267 antibody.)

Related Product Information for anti-HLA-DR1 antibody

HLA-DR1 belongs to the HLA class II beta chain paralogues. The MHC Class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. MHC Class II molecules are expressed in antigen presenting cells (APC). The beta chain is approximately 26-28 kDa. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation.