Mouse anti-Human CD2 - CD20 Antibody | anti-CD2 - CD20 antibody

CD2 FITC - CD20 PE

Cat. Num. AAA396183

• Gene Names: CD2; T11; SRBC; LFA-2
• Reactivity: Human
• Applications: Flow Cytometry, Functional Assay
• Purity: Protein A/G Chromatography
• Synonyms: CD2 - CD20; CD2 FITC - CD20 PE; anti-CD2 - CD20 antibody

• Host: Mouse
• Reactivity: Human
• Isotype: IgG2a (F)/IgG1 (PE)
• Purity/Purification: Protein A/G Chromatography
• Form/Format: Provided as sterile filtered solution in phosphate buffered saline with 0.08% sodium azide and 0.2% carrier protein
• Sequence Length: 351

• Applicable Applications for anti-CD2 - CD20 antibody: Flow Cytometry (FC/FACS)
• Immunogen: CD2=Derived from the hybridization of mouse Sp2/0 myeloma cells with spleen cells from BALB/c mice immunized with t lymphocytes activated by mixed lymphocyte culture. CD20=Derived from the hybridization of mouse Sp2/0 myeloma cells with spleen cells from BALB/c mice immunized with the LB lymphoblastoid cell line.
• Preparation and Storage: Product should be stored at 4-8 degree C. DO NOT FREEZE

Related Product Information for anti-CD2 - CD20 antibody

Identification of human T cells and subset of NK cells associated with the receptor for sheep erythocytes rosettes expressing the 45-50,000 M.W. surface antigen. Identification of human T lymphocytes in multiple stages of T cell development, including a major subset of mature peripheral T cell. Identification of CD20 on human B cells associated with approximately 10% of peripheral blood lymphocytes.

Product Categories/Family for anti-CD2 - CD20 antibody

Bi-Test Reagents (FITC/RPE); Bi-Test (tm) Reagents

NCBI and Uniprot Product Information

• NCBI GI #: 156071472
• NCBI GeneID: 914
• NCBI Accession #: NP_001758.2
• NCBI GenBank Nucleotide #: NM_001767.3
• UniProt Accession #: P06729; Q96TE5
• Molecular Weight: 39,448 Da
• NCBI Official Full Name: T-cell surface antigen CD2
• NCBI Official Synonym Full Names: CD2 molecule
• NCBI Official Symbol: CD2
• NCBI Official Synonym Symbols: T11; SRBC; LFA-2
• NCBI Protein Information: T-cell surface antigen CD2; LFA-3 receptor; rosette receptor; erythrocyte receptor; lymphocyte-function antigen-2; T-cell surface antigen T11/Leu-5; CD2 antigen (p50), sheep red blood cell receptor
• UniProt Protein Name: T-cell surface antigen CD2
• UniProt Gene Name: CD2
• UniProt Synonym Gene Names: SRBC
• UniProt Entry Name: CD2_HUMAN

NCBI Description

CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells (summarized by Sewell et al., 1986 [PubMed 3490670]). It is one of the earliest T-cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it.[supplied by OMIM, Jul 2010]

Uniprot Description

Function: CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.

Subunit structure: Interacts with CD2AP

By similarity. Interacts with PSTPIP1. Ref.11

Subcellular location: Membrane; Single-pass type I membrane protein.

Sequence similarities: Contains 1 Ig-like C2-type (immunoglobulin-like) domain.Contains 1 Ig-like V-type (immunoglobulin-like) domain.