Mouse timeless homolog (Drosophila) ELISA Kit | TIMELESS elisa kit
Mouse Protein timeless homolog, TIMELESS ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]
Uniprot Description
TIMELESS: Required for normal progression of S-phase. Involved in the circadian rhythm autoregulatory loop. Negatively regulates CLOCK-NPAS2/BMAL1-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Promotes TIPIN nuclear localiZation. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules. Belongs to the timeless family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription, coactivator/corepressor
Cellular Component: microtubule cytoskeleton; nuclear chromatin; nucleolus; nucleus
Molecular Function: protein binding; protein homodimerization activity; protein heterodimerization activity
Biological Process: mitosis; transcription, DNA-dependent; multicellular organismal development; rhythmic process; positive regulation of circadian rhythm; negative regulation of transcription from RNA polymerase II promoter; regulation of circadian rhythm; cell cycle; embryonic development; regulation of transcription, DNA-dependent; branching morphogenesis of a tube; ureteric bud branching; cell division; negative regulation of transcription, DNA-dependent; kidney development; response to DNA damage stimulus; lung development
Research Articles on TIMELESS
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Product Notes
The Mouse TIMELESS timeless (Catalog #AAA9322240) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9322240 ELISA Kit recognizes Mouse TIMELESS. It is sometimes possible for the material contained within the vial of "timeless homolog (Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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