Typical Testing Data/Standard Curve (for reference only)
Mouse Serine/threonine-protein kinase STK11 ELISA Kit | Stk11 elisa kit
Mouse Serine/threonine-protein kinase STK11 ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the serine/threonine kinase family. The encoded protein, a known tumor suppressor, activates (via phosphorylation) adenine monophosphate-activated protein kinase (AMPK) and AMPK-related kinase proteins. This upstream regulation of the AMPK pathway is thought to regulate a number of different processes, including cell metabolism, cell polarity, apoptosis and DNA damage response. Mutations in a similar gene in human have been associated with Peutz-Jeghers syndrome. Alternative splicing results in multiple transcript variants, including the S isoform which plays a potential role in spermiogenesis. [provided by RefSeq, Sep 2014]
Uniprot Description
LKB1: a S/T protein kinase of the CAMKL family. A tumor suppressor that helps control cell structure, polarity, apoptosis and energy homeostasis. Phosphorylates AGS3 (activator of G-protein signaling 3) GPR domains, regulating the interaction of GPR-containing proteins with G-proteins. A cytosolic protein complex comprised of LKB1, the pseudokinase STRAD, and the MO25 scaffold protein. Activates AMPK and several related protein kinases. AMPK plays a predominant role as the master regulator of cellular energy homeostasis, controlling downstream effectors that regulate cell growth and apoptosis in response to cellular ATP concentrations. The Lkb1/Strad/Mo25 complex can polarize single epithelial cells, leading to the formation of a brush border containing microvilli on the apical surface. Mutation in the corresponding gene causes Peutz-Jeghers syndrome (PJS), an autosomal dominant disorder characterized by benign GI tract polyps and dark skin lesions of the mouth, hands and feet. A variety of other LKB1 gene mutations have been associated with the formation of sporadic cancers in several tissues.
Protein type: Tumor suppressor; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Autophagy; Protein kinase, CAMK; Kinase, protein; CAMK group; CAMKL family; LKB subfamily
Cellular Component: cytoplasm; cytosol; membrane; mitochondrion; nucleus; protein complex
Molecular Function: ATP binding; kinase activity; LRR domain binding; magnesium ion binding; metal ion binding; nucleotide binding; p53 binding; protein binding; protein complex binding; protein kinase activator activity; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process: activation of protein kinase activity; anoikis; apoptosis; autophagy; axonogenesis; cell cycle; cell cycle arrest; cell differentiation; establishment of cell polarity; glucose homeostasis; Golgi localization; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of lipid biosynthetic process; phosphorylation; positive regulation of autophagy; positive regulation of axonogenesis; positive regulation of gluconeogenesis; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of transforming growth factor beta receptor signaling pathway; positive thymic T cell selection; protein amino acid autophosphorylation; protein amino acid phosphorylation; protein heterooligomerization; regulation of cell growth; regulation of dendrite morphogenesis; regulation of protein kinase B signaling cascade; regulation of Wnt receptor signaling pathway; response to DNA damage stimulus; response to ionizing radiation; response to lipid; spermatid development; spermatogenesis; T cell receptor signaling pathway; tissue homeostasis; vasculature development; Wnt receptor signaling pathway through beta-catenin
Research Articles on Stk11
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Product Notes
The Mouse Stk11 stk11 (Catalog #AAA2886503) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2886503 ELISA Kit recognizes Mouse Stk11. It is sometimes possible for the material contained within the vial of "Serine/threonine-protein kinase STK11, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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