Testing Data
Rabbit LKB1 Polyclonal Antibody | anti-LKB1 antibody
LKB1 Antibody
Appearance: Colorless liquid
Shelf Life: 12 months
Testing Data
Testing Data
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the serine/threonine kinase family. The encoded protein, a known tumor suppressor, activates (via phosphorylation) adenine monophosphate-activated protein kinase (AMPK) and AMPK-related kinase proteins. This upstream regulation of the AMPK pathway is thought to regulate a number of different processes, including cell metabolism, cell polarity, apoptosis and DNA damage response. Mutations in a similar gene in human have been associated with Peutz-Jeghers syndrome. Alternative splicing results in multiple transcript variants, including the S isoform which plays a potential role in spermiogenesis. [provided by RefSeq, Sep 2014]
Uniprot Description
LKB1: a S/T protein kinase of the CAMKL family. A tumor suppressor that helps control cell structure, polarity, apoptosis and energy homeostasis. Phosphorylates AGS3 (activator of G-protein signaling 3) GPR domains, regulating the interaction of GPR-containing proteins with G-proteins. A cytosolic protein complex comprised of LKB1, the pseudokinase STRAD, and the MO25 scaffold protein. Activates AMPK and several related protein kinases. AMPK plays a predominant role as the master regulator of cellular energy homeostasis, controlling downstream effectors that regulate cell growth and apoptosis in response to cellular ATP concentrations. The Lkb1/Strad/Mo25 complex can polarize single epithelial cells, leading to the formation of a brush border containing microvilli on the apical surface. Mutation in the corresponding gene causes Peutz-Jeghers syndrome (PJS), an autosomal dominant disorder characterized by benign GI tract polyps and dark skin lesions of the mouth, hands and feet. A variety of other LKB1 gene mutations have been associated with the formation of sporadic cancers in several tissues.
Protein type: Tumor suppressor; Autophagy; Kinase, protein; EC 2.7.11.1; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); CAMK group; CAMKL family; LKB subfamily
Cellular Component: protein complex; membrane; mitochondrion; cytoplasm; nucleus; cytosol
Molecular Function: p53 binding; metal ion binding; magnesium ion binding; nucleotide binding; LRR domain binding; protein kinase activity; transferase activity; protein serine/threonine kinase activity; protein binding; transferase activity, transferring phosphorus-containing groups; protein complex binding; kinase activity; protein kinase activator activity; ATP binding
Biological Process: Golgi localization; protein heterooligomerization; apoptosis; regulation of dendrite morphogenesis; protein amino acid autophosphorylation; Wnt receptor signaling pathway through beta-catenin; glucose homeostasis; response to lipid; protein amino acid phosphorylation; T cell receptor signaling pathway; anoikis; negative regulation of cell proliferation; positive regulation of gluconeogenesis; vasculature development; tissue homeostasis; regulation of cell growth; cell cycle arrest; cell differentiation; positive thymic T cell selection; regulation of Wnt receptor signaling pathway; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of protein kinase B signaling cascade; cell cycle; positive regulation of peptidyl-tyrosine phosphorylation; axonogenesis; establishment of cell polarity; positive regulation of protein kinase activity; activation of protein kinase activity; autophagy; spermatogenesis; positive regulation of axonogenesis; response to ionizing radiation; negative regulation of cell growth; phosphorylation; response to DNA damage stimulus; spermatid development
Research Articles on LKB1
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Product Notes
The LKB1 stk11 (Catalog #AAA841289) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The LKB1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's LKB1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). The antibody can be used for Western blotting (0.5-4 ug/ml). Researchers should empirically determine the suitability of the LKB1 stk11 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LKB1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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