Typical Testing Data/Standard Curve (for reference only)
Mouse Renin-1 ELISA Kit | Ren1 elisa kit
Mouse Renin-1
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
Background: The secretion of renin from granules stored in renal juxtaglomerular cells plays a key role in blood pressure homeostasis. The synthesis and release of renin and the extent of granulation is regulated by several mechanisms including signaling from the macula densa, neuronal input, and blood pressure. Clark AF et al study indicate that expression of the Ren-1(d) gene is a prerequisite for the formation of storage granules, even though the related protein renin-2 is present in these mice, suggesting that renin-1(d) and renin-2 are secreted by distinct pathways in vivo. The synthesis of renin and other biologically active polypeptides in the granular convoluted tubule cells of the mouse submandibular gland (SMG) is regulated by androgen and thyroid hormones. The androgen and thyroid hormones influence levels of renin-1 in mouse SMG primarily by regulating the amount of renin-1 mRNA available for translation.
NCBI and Uniprot Product Information
Uniprot Description
REN: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Interacts with ATP6AP2. Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing. Belongs to the peptidase A1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.4.23.15; Protease; Secreted; Secreted, signal peptide
Cellular Component: cytoplasm; extracellular space; intracellular; lysosome
Molecular Function: aspartic-type endopeptidase activity; endopeptidase activity; insulin-like growth factor receptor binding; peptidase activity; receptor binding
Biological Process: angiotensin maturation; cell maturation; drinking behavior; establishment of blood-nerve barrier; hormone-mediated signaling; kidney development; male gonad development; mesonephros development; proteolysis; regulation of blood pressure; regulation of MAPKKK cascade; renin-angiotensin regulation of aldosterone production; renin-angiotensin regulation of blood volume; response to cAMP; response to drug; response to organic substance
Research Articles on Ren1
Similar Products
Product Notes
The Mouse Ren1 ren1 (Catalog #AAA355778) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA355778 ELISA Kit recognizes Mouse Ren1. It is sometimes possible for the material contained within the vial of "Renin-1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
