Mouse Receptor-type tyrosine-protein phosphatase U (PTPRU) ELISA Kit | PTPRU elisa kit
Mouse Receptor-type tyrosine-protein phosphatase U (PTPRU) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Alternatively spliced transcript variants have been reported. [provided by RefSeq, Aug 2010]
Uniprot Description
PTPRU: Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis. Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; EC 3.1.3.48; Receptor protein phosphatase, tyrosine; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p35.3
Cellular Component: integral to plasma membrane; plasma membrane; intercellular junction
Molecular Function: protein binding; transmembrane receptor protein tyrosine phosphatase activity; beta-catenin binding; protein tyrosine phosphatase activity
Biological Process: negative regulation of cell proliferation; organ regeneration; cell-cell adhesion; response to glucocorticoid stimulus; homotypic cell-cell adhesion; Wnt receptor signaling pathway through beta-catenin; cell differentiation; cell adhesion; protein amino acid dephosphorylation; negative regulation of cell migration; transmembrane receptor protein tyrosine phosphatase signaling pathway
Research Articles on PTPRU
Similar Products
Product Notes
The Mouse PTPRU ptpru (Catalog #AAA7228358) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7228358 ELISA Kit recognizes Mouse PTPRU. It is sometimes possible for the material contained within the vial of "Receptor-type tyrosine-protein phosphatase U (PTPRU), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
