Mouse RAD21 homolog (S. pombe) ELISA Kit | RAD21 elisa kit
Mouse Double-strand-break repair protein rad21 homolog, RAD21 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
RAD21: Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway. Cohesin complexes are composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domain, RAD21 which link them, and one STAG protein (STAG1, STAG2 or STAG3), which interacts with RAD21. Found in a complex with SMC1A, SMC3, CDCA5, PDS5A/APRIN and PDS5B/SCC-112. Interacts with PDS5B and WAPAL; the interaction is direct. Belongs to the rad21 family.
Cellular Component: nucleoplasm; cohesin complex; nuclear chromosome; condensed nuclear chromosome; membrane; chromosome; chromatin; nucleus; chromosome, pericentric region
Molecular Function: protein binding
Biological Process: regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter; mitosis; apoptosis; cell division; positive regulation of transcription from RNA polymerase II promoter; DNA repair; cell cycle; response to DNA damage stimulus; chromosome segregation
Research Articles on RAD21
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Product Notes
The Mouse RAD21 rad21 (Catalog #AAA9333760) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9333760 ELISA Kit recognizes Mouse RAD21. It is sometimes possible for the material contained within the vial of "RAD21 homolog (S. pombe), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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