Mouse numb homolog (Drosophila) ELISA Kit | NUMB elisa kit

Mouse Protein numb homolog, NUMB ELISA Kit

Cat. Num. AAA9317895

• Gene Names: Numb; Nb
• Reactivity: Mouse
• Synonyms: numb homolog (Drosophila); Mouse Protein numb homolog; NUMB ELISA Kit; Mouse Protein numb homolog (NUMB) ELISA kit; S171; numb homolog; NUMB elisa kit

• Reactivity: Mouse

• Preparation and Storage: Store all reagents at 2-8 degree C

NCBI and Uniprot Product Information

• NCBI GI #: 209862959
• NCBI GeneID: 18222
• NCBI Accession #: NP_001129547.1
• NCBI GenBank Nucleotide #: NM_001136075.2
• UniProt Accession #: Q9QZS3; P70422; Q8CIB1; Q9DC57; Q9QZR1; Q9QZS4
• Molecular Weight: 70,813 Da
• NCBI Official Full Name: protein numb homolog isoform 1
• NCBI Official Synonym Full Names: numb gene homolog (Drosophila)
• NCBI Official Symbol: Numb
• NCBI Official Synonym Symbols: Nb
• NCBI Protein Information: protein numb homolog
• UniProt Protein Name: Protein numb homolog
• Protein Family: Protein numb
• UniProt Gene Name: Numb
• UniProt Synonym Gene Names: m-Nb; m-Numb
• UniProt Entry Name: NUMB_MOUSE

NCBI Description

This gene encodes a conserved protein that is distributed asymmetrically during cell division in the developing embryo. The encoded protein participates in cell fate decisions by interacting with the Notch receptor. Loss of function of this gene results in severe defects in neural development and loss of viability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Uniprot Description

NUMB: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. May also mediate local repair of brain ventricular wall damage. Interacts with CDH1 and TFAP2B. Interacts with EPS15, LNX and NOTCH1. May interact with DUOXA1. Interacts with RALBP1 in a complex also containing EPN1 and TFAP2A during interphase and mitosis. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell development/differentiation

Cellular Component: extrinsic to plasma membrane; focal adhesion; membrane; clathrin-coated vesicle; apical part of cell; basolateral plasma membrane; early endosome; cytoplasmic membrane-bound vesicle; cytoplasm; apical plasma membrane; nucleus

Molecular Function: protein binding; cadherin binding; beta-catenin binding; alpha-catenin binding

Biological Process: positive regulation of polarized epithelial cell differentiation; nervous system development; positive regulation of neurogenesis; axonogenesis; regulation of neuron differentiation; multicellular organismal development; neuroblast proliferation; forebrain development; negative regulation of Notch signaling pathway; neuroblast division in the subventricular zone; positive regulation of dendrite morphogenesis; lateral ventricle development; positive regulation of cell migration