Mouse Nuclear receptor subfamily 4 group A member 3, NR4A3 ELISA Kit | NR4A3 elisa kit

Mouse Nuclear receptor subfamily 4 group A member 3, NR4A3 ELISA Kit

Cat. Num. AAA1605483

• Gene Names: Nr4a3; NOR-2
• Reactivity: Mouse
• Synonyms: Nuclear receptor subfamily 4 group A member 3; NR4A3; Mouse Nuclear receptor subfamily 4 group A member 3; NR4A3 ELISA Kit; NR4A3 elisa kit

• Reactivity: Mouse
• Sequence Length: 628

• Assay Type: Quantitative Sandwich
• Samples: Serum, plasma, cell culture supernates, cell lysates, tissue homogenates and other biological fluids.
• Detection Range: 15 ng/L-3000 ng/L
• Sensitivity: 7.76 ng/L
• Preparation and Storage: Store at 2 to 8 degree C for 6 months.

NCBI and Uniprot Product Information

• NCBI GI #: 13994173
• NCBI GeneID: 58853
• NCBI GenBank Nucleotide #: NP_113816.1
• UniProt Accession #: P51179
• NCBI Official Full Name: nuclear receptor subfamily 4 group A member 3
• NCBI Official Synonym Full Names: nuclear receptor subfamily 4, group A, member 3
• NCBI Official Symbol: Nr4a3
• NCBI Official Synonym Symbols: NOR-2
• NCBI Protein Information: nuclear receptor subfamily 4 group A member 3
• UniProt Protein Name: Nuclear receptor subfamily 4 group A member 3
• Protein Family: Nuclear receptor subfamily
• UniProt Gene Name: Nr4a3
• UniProt Synonym Gene Names: Nor1

NCBI Description

nuclear orphan receptor; involved in regulating transcription [RGD, Feb 2006]

Uniprot Description

Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner (PubMed:7811288). Induces gene expression by binding as monomers to the NR4A1 response element (NBRE) 5'-AAAAGGTCA-3' site and as homodimers to the Nur response element (NurRE) site in the promoter of their regulated target genes (PubMed:10523643). Plays a role in the regulation of proliferation, survival and differentiation of many different cell types and also in metabolism and inflammation. Mediates proliferation of vascular smooth muscle, myeloid progenitor cell and type B pancreatic cells; promotes mitogen-induced vascular smooth muscle cell proliferation through transactivation of SKP2 promoter by binding a NBRE site (). Upon PDGF stimulation, stimulates vascular smooth muscle cell proliferation by regulating CCND1 and CCND2 expression (PubMed:16945922). In islets, induces type B pancreatic cell proliferation through up-regulation of genes that activate cell cycle, as well as genes that cause degradation of the CDKN1A (PubMed:24706823). Negatively regulates myeloid progenitor cell proliferation by repressing RUNX1 in a NBRE site-independent manner. During inner ear, plays a role as a key mediator of the proliferative growth phase of semicircular canal development (). Mediates also survival of neuron and smooth muscle cells; mediates CREB-induced neuronal survival, and during hippocampus development, plays a critical role in pyramidal cell survival and axonal guidance. Is required for S phase entry of the cell cycle and survival of smooth muscle cells by inducing CCND1, resulting in RB1 phosphorylation. Binds to NBRE motif in CCND1 promoter, resulting in the activation of the promoter and CCND1 transcription (). Plays also a role in inflammation; Upon TNF stimulation, mediates monocyte adhesion by inducing the expression of VCAM1 and ICAM1 by binding to the NBRE consensus site (). In mast cells activated by Fc-epsilon receptor cross-linking, promotes the synthesis and release of cytokines but impairs events leading to degranulation. Plays also a role in metabolism; by modulating feeding behavior; and by playing a role in energy balance by inhibiting the glucocorticoid-induced orexigenic neuropeptides AGRP expression, at least in part by forming a complex with activated NR3C1 on the AGRP-glucocorticoid response element (GRE), and thus weakening the DNA binding activity of NR3C1. Upon catecholamines stimulation, regulates gene expression that controls oxidative metabolism in skeletal muscle (). Plays a role in glucose transport by regulating translocation of the SLC2A4 glucose transporter to the cell surface (). Finally, during gastrulation plays a crucial role in the formation of anterior mesoderm by controlling cell migration (). Also participates in cardiac hypertrophy by activating PARP1 (PubMed:25625556).