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Mouse Nephrin (NPHN) ELISA Kit | NPHN elisa kit

Mouse Nephrin (NPHN) Mini Samples ELISA Kit

Gene Names
Nphs1; nephrin; NephrinB
Reactivity
Mouse
Synonyms
Nephrin (NPHN); Mouse Nephrin (NPHN) Mini Samples ELISA Kit; NPHS1; CNF; Nephrosis 1; Congenital Finnish Type; Renal glomerulus-specific cell adhesion receptor; NPHN elisa kit
Ordering
 
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For Research Use Only!
Reactivity
Mouse
Sequence Length
1256
Assay Type
Double-antibody Sandwich ELISA for Antigen Detection
Samples
Urine, Tissue homogenates, cell lysates, cell culture supernates and other biological fluids
Detection Range
0.312-20ng/mL
Sensitivity
0.113ng/mL
Product Categories/Family for NPHN elisa kit

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
135,352 Da
NCBI Official Full Name
nephrin
NCBI Official Synonym Full Names
nephrosis 1, nephrin
NCBI Official Symbol
Nphs1
NCBI Official Synonym Symbols
nephrin; NephrinB
NCBI Protein Information
nephrin
UniProt Protein Name
Nephrin
UniProt Gene Name
Nphs1
UniProt Synonym Gene Names
Nphn

Uniprot Description

NPHS1: Seems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion. Interacts with CD2AP (via C-terminal domain). Interacts with MAGI1 (via PDZ 2 and 3 domains) forming a tripartite complex with IGSF5/JAM4. Interacts with DDN; the interaction is direct. Self-associates (via the Ig-like domains). Also interacts (via the Ig-like domains) with KIRREL/NEPH1 and KIRREL2; the interaction with KIRREL is dependent on KIRREL glycosylation. Forms a complex with ACTN4, CASK, IQGAP1, MAGI2, SPTAN1 and SPTBN1. Interacts with NPHS2. Specifically expressed in podocytes of kidney glomeruli. Belongs to the immunoglobulin superfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7|7 B1

Cellular Component: cell projection; integral to membrane; integral to plasma membrane; lipid raft; membrane; plasma membrane; protein complex

Molecular Function: alpha-actinin binding; myosin binding; protein binding; protein domain specific binding; spectrin binding

Biological Process: cell adhesion; JNK cascade; MAPKKK cascade; myoblast fusion; positive regulation of actin filament polymerization; skeletal muscle development

Research Articles on NPHN

1. interaction of full-length suPAR with alphavbeta3 integrin expressed on podocytes results in down-modulation of nephrin that may affect kidney functionality in different human pathologies characterized by increased concentration of suPAR.

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Product Notes

The Mouse NPHN nphs1 (Catalog #AAA2087714) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2087714 ELISA Kit recognizes Mouse NPHN. It is sometimes possible for the material contained within the vial of "Nephrin (NPHN), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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