Mouse G protein-activated inward rectifier potassium channel 1, KCNJ3/GIRK1 ELISA Kit | KCNJ3/GIRK1 elisa kit
Mouse G protein-activated inward rectifier potassium channel 1, KCNJ3/GIRK1 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and plays an important role in regulating heartbeat. It associates with three other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex that also couples to neurotransmitter receptors in the brain and whereby channel activation can inhibit action potential firing by hyperpolarizing the plasma membrane. These multimeric G-protein-gated inwardly-rectifying potassium (GIRK) channels may play a role in the pathophysiology of epilepsy, addiction, Down's syndrome, ataxia, and Parkinson's disease. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, May 2012]
Uniprot Description
This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.
Research Articles on KCNJ3/GIRK1
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Product Notes
The Mouse KCNJ3/GIRK1 kcnj3 (Catalog #AAA1600963) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA1600963 ELISA Kit recognizes Mouse KCNJ3/GIRK1. It is sometimes possible for the material contained within the vial of "G protein-activated inward rectifier potassium channel 1, KCNJ3/GIRK1, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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