Mouse Ficolin 3 (FCN3) ELISA Kit | FCN3 elisa kit
Mouse Ficolin 3 (FCN3) ELISA Kit
No significant cross-reactivity or interference between Ficolin 3 (FCN3) and analogues was observed.
To minimize extra influence on the performance, operation procedures and lab conditions, especially room temperature, air humidity, incubator temperature should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same operator from the beginning to the end.
NCBI and Uniprot Product Information
NCBI Description
Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified. [provided by RefSeq, Jul 2008]
Uniprot Description
FCN3: May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota. Defects in FCN3 are the cause of ficolin 3 deficiency (FCN3D). FCN3D is a disorder characterized by immunodeficiency, recurrent infections, brain abscesses and recurrent warts on the fingers. Affected individuals have normal levels of lymphocytes, normal T-cell responses, and normal antibodies, but a selective deficient antibody response to pneumococcal polysaccharide vaccine. Belongs to the ficolin lectin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1p36.11
Cellular Component: collagen; extracellular region
Molecular Function: antigen binding; carbohydrate binding; metal ion binding; protein binding; serine-type endopeptidase activity
Biological Process: complement activation; complement activation, lectin pathway; defense response to virus; negative regulation of virion penetration into host cell; proteolysis; recognition of apoptotic cell
Disease: Immunodeficiency Due To Ficolin 3 Deficiency
Research Articles on FCN3
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Product Notes
The Mouse FCN3 fcn3 (Catalog #AAA2097980) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2097980 ELISA Kit recognizes Mouse FCN3. It is sometimes possible for the material contained within the vial of "Ficolin 3 (FCN3), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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