Mouse CD22 ELISA Kit | CD22 elisa kit

Mouse CD22 ELISA Kit

Cat. Num. AAA8244591

• Gene Names: Cd22; Lyb8; Lyb-8; A530093D23
• Reactivity: Mouse
• Applications: ELISA
• Synonyms: CD22; Mouse CD22 ELISA Kit; SIGLEC2; B-cell receptor CD22; B-lymphocyte cell adhesion molecule; BL-CAM; Sialic acid-binding Ig-like lectin 2; Siglec-2; T-cell surface antigen Leu-14; CD22 elisa kit

• Reactivity: Mouse
• Specificity: The Mouse CD22 ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Mouse CD22 proteins within the range of 156 pg/ml - 10000 pg/ml.
• Sequence Length: 862

• Applicable Applications for CD22 elisa kit: Sandwich ELISA (EIA)
• Samples: Cell culture supernatants, serum, plasma
• Sensitivity: < 10 pg/ml
• Preparation and Storage: Shipped and store at 4 degree C for 6 months, store at -20 degree C for one year. Avoid freeze/thaw cycles.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for CD22 elisa kit

Background/Introduction: CD22 or cluster of differentiation-22, is a molecule belonging to the SIGLEC family of lectins. This gene is mapped to 19q13.2. It is found on the surface of mature B cells and to a lesser extent on some immature B cells. Generally speaking, CD22 is a regulatory molecule that prevents the overactivation of the immune system and the development of autoimmune diseases. It is a negative regulator of antigen receptor signaling whose onset of expression at the mature B cell stage may serve to raise the antigen concentration threshold required for B cell triggering. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signalling. This gene can downmodulate signaling through the IgM and IgD B-cell receptors(BCRs), but not through the IgG BCR, because the IgG cytoplasmic tail prevents CD22 phosphorylation and actually enhances IgG-BCR signaling.

NCBI and Uniprot Product Information

• NCBI GI #: 461664
• NCBI GeneID: 12483
• UniProt Accession #: P35329; Q9JHL2; Q9JJX9; Q9JJY0; Q9JJY1; Q9R056; Q9R094; Q9WU51
• Molecular Weight: 92,857 Da
• NCBI Official Full Name: B-cell receptor CD22
• NCBI Official Synonym Full Names: CD22 antigen
• NCBI Official Symbol: Cd22
• NCBI Official Synonym Symbols: Lyb8; Lyb-8; A530093D23
• NCBI Protein Information: B-cell receptor CD22
• UniProt Protein Name: B-cell receptor CD22
• Protein Family: CD226 antigen
• UniProt Gene Name: Cd22
• UniProt Synonym Gene Names: Lyb-8; Siglec2; BL-CAM; Siglec-2
• UniProt Entry Name: CD22_MOUSE

Uniprot Description

CD22: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell surface

Cellular Component: external side of plasma membrane; integral to membrane; integral to plasma membrane; membrane; plasma membrane

Molecular Function: carbohydrate binding; coreceptor activity; protein binding

Biological Process: cell adhesion; cell surface receptor linked signal transduction