Mouse AATF ELISA Kit | AATF elisa kit
Mouse Protein AATF (AATF) ELISA Kit
Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.
Inter-assay Precision (Precision between assays)
Three samples of known concentration were tested in forty separate assays to assess inter-assay precision.
CV (%) = SD/meanX100
Intra-Assay: CV
Inter-Assay: CV
NCBI and Uniprot Product Information
Uniprot Description
AATF: May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. Belongs to the AATF family.
Protein type: Nucleolus; RNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 11|11 C
Cellular Component: cytoplasm; Golgi apparatus; nucleolus; nucleus
Molecular Function: DNA binding transcription factor activity; leucine zipper domain binding; protein binding; protein domain specific binding; RNA binding; tau protein binding
Biological Process: cell adhesion; embryonic cleavage; negative regulation of amyloid precursor protein biosynthetic process; negative regulation of apoptosis; negative regulation of superoxide release; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; regulation of mitotic cell cycle; regulation of transcription from RNA polymerase II promoter; ribosome biogenesis
Research Articles on AATF
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Product Notes
The Mouse AATF aatf (Catalog #AAA285981) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA285981 ELISA Kit recognizes Mouse AATF. It is sometimes possible for the material contained within the vial of "AATF, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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