Mouse FGF7 (Fibroblast Growth Factor 7) CLIA Kit | FGF7 clia kit

Mouse FGF7 (Fibroblast Growth Factor 7) CLIA Kit

Cat. Num. AAA2531628

• Gene Names: FGF7; KGF; HBGF-7
• Reactivity: Mouse
• Synonyms: FGF7 (Fibroblast Growth Factor 7); Mouse FGF7 (Fibroblast Growth Factor 7) CLIA Kit; FGF-7; KGF; HBGF-7; FGF7 clia kit

• Reactivity: Mouse
• Specificity: This kit recognizes natural and recombinant FGF7. No significant cross-reactivity or interference between FGF7 and analogues was observed.
• Sequence Length: 194

• Assay Type: Sandwich
• Detection Range: 7.813-500pg/mL
• Sensitivity: Min: 4.688pg/mL; Max: 500pg/mL

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for FGF7 clia kit

Intended Uses: This CLIA kit applies to the in vitro quantitative determination of FGF7 concentrations in serum, plasma and other biological fluids.

Principle of the Assay: This kit uses Sandwich-CLIA as the method. The micro CLIA plate provided in this kit has been pre-coated with an antibody specific to FGF7. Standards or samples are added to the appropriate micro CLIA plate wells and combined with the specific antibody. Then a biotinylated detection antibody specific for FGF7 and Avidin-Horseradish Peroxidase (HRP) conjugate is added to each micro plate well successively and incubated. Free components are washed away. The substrate solution is added to each well. Only those wells that contain FGF7, biotinylated detection antibody and Avidin-HRP conjugate will appear fluorescence. The Relative light unit (RLU) value is measured spectrophotometrically by the Chemiluminescence immunoassay analyzer. The RLU value is positively associated with the concentration of FGF7. You can calculate the concentration of FGF7 in the samples by comparing the RLU value of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 4503705
• NCBI GeneID: 2252
• NCBI Accession #: NP_002000.1
• NCBI GenBank Nucleotide #: NM_002009.3
• Molecular Weight: 11,520 Da
• NCBI Official Full Name: fibroblast growth factor 7
• NCBI Official Synonym Full Names: fibroblast growth factor 7
• NCBI Official Symbol: FGF7
• NCBI Official Synonym Symbols: KGF; HBGF-7
• NCBI Protein Information: fibroblast growth factor 7
• UniProt Protein Name: Fibroblast growth factor 7
• Protein Family: Fibroblast growth factor
• UniProt Gene Name: FGF7
• UniProt Synonym Gene Names: KGF; FGF-7; HBGF-7
• UniProt Entry Name: FGF7_HUMAN

NCBI Description

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis. [provided by RefSeq, Jul 2008]

Uniprot Description

FGF7: Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation. Belongs to the heparin-binding growth factors family.

Protein type: Cytokine; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 15q21.2

Cellular Component: Golgi apparatus; extracellular space; extracellular region

Molecular Function: heparin binding; protein binding; growth factor activity; type 2 fibroblast growth factor receptor binding; chemoattractant activity

Biological Process: axon guidance; epidermis development; nerve growth factor receptor signaling pathway; activation of MAPKK activity; wound healing; positive regulation of transcription, DNA-dependent; mesenchymal cell proliferation; signal transduction; ovarian follicle development; positive chemotaxis; small GTPase mediated signal transduction; positive regulation of cell proliferation; response to wounding; epidermal growth factor receptor signaling pathway; positive regulation of keratinocyte migration; phosphoinositide-mediated signaling; hair follicle morphogenesis; fibroblast growth factor receptor signaling pathway; MAPKKK cascade; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of cell division; actin cytoskeleton reorganization; Ras protein signal transduction; insulin receptor signaling pathway; phosphatidylcholine biosynthetic process; innate immune response; vascular endothelial growth factor receptor signaling pathway; positive regulation of defense response to virus by host; surfactant homeostasis; positive regulation of epithelial cell proliferation