LAG-3:Fc Active Protein
LAG-3:Fc, Recombinant, Mouse (Lymphocyte Activation Gene-3, FDC Protein, CD223)
Purity
Highly Purified>95% (SDS-PAGE)
Synonyms
LAG-3:Fc; Recombinant; Mouse (Lymphocyte Activation Gene-3; FDC Protein; CD223); LAG-3:Fc active protein
Host
Mouse, CHO cells
Specificity
Binds to human and mouse MHC class II.
Purity/Purification
Highly Purified
>95% (SDS-PAGE)
>95% (SDS-PAGE)
Form/Format
In PBS.
Sequence
The sequence coding for the 4 extracellular Ig-like domains of mouse LAG-3 (D1-D4) is fused to the Fc portion of mouse IgG2a (hinge-CH2-CH3).
Biological Activity
Induces maturation of mouse dendritic cells in vitro. Induces CD4 and CD8 antigen-specific T cells responses when coinjected s.c. in mice, together with the antigen.
Preparation and Storage
Short-term Storage: +4 degree C
Long-term Storage: -20 degree C
Stable for at least 6 months after receipt when stored at +4 degree C.
Long-term Storage: -20 degree C
Stable for at least 6 months after receipt when stored at +4 degree C.
Related Product Information for LAG-3:Fc active protein
Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.
Product Categories/Family for LAG-3:Fc active protein
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Product Notes
The LAG-3:Fc (Catalog #AAA637052) is an Active Protein produced from Mouse, CHO cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: The sequence coding for the 4 extracellu lar Ig-like domains of mouse LAG-3 (D1-D4) is fused to the Fc portion of mouse IgG2a (hinge-CH2 -CH3). It is sometimes possible for the material contained within the vial of "LAG-3:Fc, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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