LIX active protein

LIX protein (Mouse)

Cat. Num. AAA538192

• Gene Names: Cxcl5; LIX; GCP-2; Scyb5; Scyb6; ENA-78; AMCF-II
• Applications: User optimized
• Purity: > 98% pure
• Synonyms: LIX; LIX protein (Mouse); CXCL5 protein; ENA-78 protein; LIX active protein

• Host: Mouse
• Purity/Purification: > 98% pure
• Form/Format: Lyophilized with no additives. Reconstitute in water to a concentration of 0.1-1.0 mg/ml.
• Sequence: Region of LIX protein corresponding to amino acids TELRCVCLTV TPKINPKLIA NLEVIPAGPQ CPTVEVIAKL KNQKEVCLDP EAPVIKKIIQ KILGSDKKKA.
• Sequence Length: 132

• Applicable Applications for LIX active protein: User optimized
• Protein Type: Recombinant
• Biological Significance: The Mouse homolog of ENA-78 is called LIX. LIX is a CXC chemokine that signals through the CXCR2 receptor. It is expressed in monocytes, platelets, endothelial cells, and mast cells. LIX is a chemoattractant for neutrophils. The two naturally occurring variants of LIX; LIX 1-78 (GCP-2) and LIX 9-78 (GCP-2), contain 78 and 70 amino acid residues, respectively. LIX contains the four conserved cysteine residues present in CXC chemokines, and also contains the ?ELR? motif common to CXC chemokine that bind to the CXCR1 and CXCR2 receptors.
• Bioactivity: Determined by its ability to chemoattract human neutrophils using a concentration range of 10.0-100.0 ng/ml.
• Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
• Expression System: E Coli
• Preparation and Storage: Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Related Product Information for LIX active protein

Purified recombinant Mouse LIX protein

Product Categories/Family for LIX active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 950159
• NCBI GeneID: 20311
• UniProt Accession #: P50228; Q8K3I3
• Molecular Weight: 7.6 kDa
• NCBI Official Full Name: LIX
• NCBI Official Synonym Full Names: chemokine (C-X-C motif) ligand 5
• NCBI Official Symbol: Cxcl5
• NCBI Official Synonym Symbols: LIX; GCP-2; Scyb5; Scyb6; ENA-78; AMCF-II
• NCBI Protein Information: C-X-C motif chemokine 5
• UniProt Protein Name: C-X-C motif chemokine 5
• Protein Family: LIX1-like protein
• UniProt Gene Name: Cxcl5
• UniProt Synonym Gene Names: Scyb5
• UniProt Entry Name: CXCL5_MOUSE

NCBI Description

This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils and to have homeostatic and inflammatory functions. In mouse, deficiency of this gene is associated with increased lung inflammation that is neutrophil-dependent. [provided by RefSeq, May 2013]

Uniprot Description

CXCL6: Chemotactic for neutrophil granulocytes. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide

Cellular Component: extracellular space; extracellular region

Molecular Function: chemokine activity; CXCR chemokine receptor binding; cytokine activity

Biological Process: G-protein coupled receptor protein signaling pathway; organ regeneration; positive regulation of JAK-STAT cascade; cytokine production; positive regulation of leukocyte chemotaxis; response to lipopolysaccharide; immune response; inflammatory response; chemotaxis; regulation of chemokine production; leukocyte homeostasis; regulation of cell proliferation