IL21 active protein

IL21 protein (Mouse)

Cat. Num. AAA539526

• Gene Names: IL21; Za11; IL-21; CVID11
• Applications: User optimized
• Purity: > 98% pure
• Synonyms: IL21; IL21 protein (Mouse); IL-21 protein; IL-21; IL 21 protein; Interleukin 21 protein; IL 21; IL21 active protein

• Host: Mouse
• Purity/Purification: > 98% pure
• Form/Format: Supplied as a lyophilized powder.
• Sequence: Region of IL21 protein corresponding to amino acids MHKSSPQGPD RLLIRLRHLI DIVEQLKIYE NDLDPELLSA PQDVKGHCEH AAFACFQKAK LKPSNPGNNK TFIIDLVAQL RRRLPARRGG KKQKHIAKCP SCDSYEKRTP KEFLERLKWL LQKMIHQHLS.
• Sequence Length: 162

• Applicable Applications for IL21 active protein: User optimized
• Protein Type: Recombinant
• Biological Significance: IL21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen-specific responses of immune cells. The biological effects of IL21 include induction of differentiation of T-cells-stimulated-B-cells into plasma cells and memory B-cells, stimulation (in conjunction) with IL4 of IgG production, and induction of apoptotic effects in na
• Bioactivity: Determined by a cell proliferation assay using modified Ba/F3 cells. The expected ED50for this effect is 10-50 ng/ml.
• Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
• Expression System: E Coli
• Preparation and Storage: Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Related Product Information for IL21 active protein

Purified recombinant Mouse IL21 protein

Product Categories/Family for IL21 active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 11141875
• NCBI GeneID: 59067
• NCBI Accession #: NP_068575.1
• NCBI GenBank Nucleotide #: NM_021803.3
• UniProt Accession #: Q9HBE4; A5J0L4
• Molecular Weight: 15 kDa
• NCBI Official Full Name: interleukin-21 isoform 1
• NCBI Official Synonym Full Names: interleukin 21
• NCBI Official Symbol: IL21
• NCBI Official Synonym Symbols: Za11; IL-21; CVID11
• NCBI Protein Information: interleukin-21
• UniProt Protein Name: Interleukin-21
• Protein Family: Interleukin
• UniProt Gene Name: IL21
• UniProt Synonym Gene Names: IL-21
• UniProt Entry Name: IL21_HUMAN

NCBI Description

This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Uniprot Description

IL21: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. Belongs to the IL-15/IL-21 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine; Secreted, signal peptide; Secreted; Apoptosis; Cell development/differentiation

Chromosomal Location of Human Ortholog: 4q26-q27

Cellular Component: extracellular space

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor binding; interleukin-2 receptor binding; cytokine activity

Biological Process: positive regulation of interleukin-17 production; positive regulation of natural killer cell cytokine production; cell maturation; positive regulation of natural killer cell mediated cytotoxicity; signal transduction; positive regulation of interleukin-10 production; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of natural killer cell differentiation; positive regulation of tissue remodeling; positive regulation of tyrosine phosphorylation of Stat1 protein; positive regulation of cell proliferation; positive regulation of B cell proliferation; immune response; positive regulation of T cell proliferation; positive regulation of inflammatory response; positive regulation of interferon-gamma biosynthetic process

Disease: Immunodeficiency, Common Variable, 11