IL11 active protein

IL11 protein (Mouse)

Cat. Num. AAA539507

• Gene Names: IL11; AGIF; IL-11
• Applications: User optimized
• Purity: > 98% pure
• Synonyms: IL11; IL11 protein (Mouse); Interleukin 11 protein; AGIF protein; IL 11 protein; IL-11 protein; IL-11; Adipogenesis inhibitory factor protein; IL 11; IL11 active protein

• Host: Mouse
• Purity/Purification: > 98% pure
• Form/Format: Supplied as a lyophilized powder.
• Sequence: Region of IL11 protein corresponding to amino acids MPGPPAGSPR VSSDPRADLD SAVLLTRSLL ADTRQLAAQM RDKFPADGDH SLDSLPTLAM SAGTLGSLQL PGVLTRLRVD LMSYLRHVQW LRRAGGPSLK TLEPELGALQ ARLERLLRRL QLLMSRLALP QAAPDQPVIP LGPPASAWGS IRAAHAILGG LHLTLDWAVR GLLLLKTRL.
• Sequence Length: 199

• Applicable Applications for IL11 active protein: User optimized
• Protein Type: Recombinant
• Biological Significance: IL11 is a multifunctional cytokine produced by stromal cells such as fibroblasts, epithelial cells and osteoclasts. It is expressed in a wide variety of tissues including thymus, lung, bone, connective tissue and central nervous system. IL11 plays an important regulatory role in hematopoiesis by stimulating growth of myeloid, erythroid and megakaryocyte progenitor cells. It also regulates bone metabolism, inhibits production of proinflammatory cytokines and protects against gastromucosal injury.
• Bioactivity: The ED50 was determined by the dose-dependent stimulation of the proliferation of Mouse T11 cells is approximately 2.0 ng/ml, corresponding to a specific activity of approximately 5 x 10^5 units/mg.
• Endotoxin Levels: Endotoxin level is less than 0.1 ng per ug (1 EU/ug).
• Expression System: E Coli
• Preparation and Storage: Store at 4 degree C until reconstitution. Following reconstitution aliquot and freeze at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Related Product Information for IL11 active protein

Purified recombinant Mouse IL11 protein

Product Categories/Family for IL11 active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 10834994
• NCBI GeneID: 3589
• NCBI Accession #: NP_000632.1
• NCBI GenBank Nucleotide #: NM_000641.3
• UniProt Accession #: P20809; Q96EB4; B4DQV5
• Molecular Weight: 19.1 kDa
• NCBI Official Full Name: interleukin-11 isoform 1
• NCBI Official Synonym Full Names: interleukin 11
• NCBI Official Symbol: IL11
• NCBI Official Synonym Symbols: AGIF; IL-11
• NCBI Protein Information: interleukin-11
• UniProt Protein Name: Interleukin-11
• Protein Family: Interleukin
• UniProt Gene Name: IL11
• UniProt Synonym Gene Names: AGIF
• UniProt Entry Name: IL11_HUMAN

NCBI Description

The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2012]

Uniprot Description

IL11: Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Belongs to the IL-6 superfamily.

Protein type: Motility/polarity/chemotaxis; Cytokine; Secreted, signal peptide; Cell cycle regulation

Chromosomal Location of Human Ortholog: 19q13.3-q13.4

Cellular Component: extracellular space; cytoplasm; extracellular region

Molecular Function: growth factor activity; cytokine activity; interleukin-11 receptor binding

Biological Process: fat cell differentiation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of MAPKKK cascade; cell-cell signaling; megakaryocyte differentiation; B cell differentiation; negative regulation of hormone secretion; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of peptidyl-serine phosphorylation