GCSF active protein

GCSF protein

Cat. Num. AAA5304347

• Gene Names: CSF3; GCSF; CSF3OS; C17orf33
• Purity: > 98% pure; GCSF protein was purified using a a proprietary chromatographic technique.
• Synonyms: GCSF; GCSF protein; GM-CSF beta protein; pluripoietin protein; CSF-3 protein; Granulocyte Colony-Stimulating Factor protein; MGI-1G protein; GCSF active protein

• Host: Mouse
• Purity/Purification: > 98% pure; GCSF protein was purified using a a proprietary chromatographic technique.
• Form/Format: Sterile filtered and lyophilized from 5 mM NaCitrate, pH 4.0
• Sequence Length: 168

• Protein Type: Recombinant
• Biological Significance: G-CSF is a potent stimulator of bone marrow cells, especially those of neutrophil lineage. In addition, G-CSF can enhance the survival and activate the immunological functions of mature neutrophils. Murine G-CSF is a 19.0 kDa protein containing 179 amino acid residues.
• Bioactivity: The ED50 as determined by the dose-dependent stimulation of the proliferation of murine M-NFS-60 cells is < 0.005 ng/ml, corresponding to a specific activity of > 2 x 10^7 units/mg
• Endotoxin Levels: <0.1 ng/ug
• Expression System: E Coli
• Preparation and Storage: Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Related Product Information for GCSF active protein

Purified recombinant Mouse GCSF protein

Product Categories/Family for GCSF active protein

Cytokines & Growth Factors

NCBI and Uniprot Product Information

• NCBI GI #: 296011057
• NCBI GeneID: 1440
• NCBI Accession #: NP_001171618.1
• NCBI GenBank Nucleotide #: NM_001178147.1
• Molecular Weight: 19 kDa
• NCBI Official Full Name: granulocyte colony-stimulating factor isoform d
• NCBI Official Synonym Full Names: colony stimulating factor 3 (granulocyte)
• NCBI Official Symbol: CSF3
• NCBI Official Synonym Symbols: GCSF; CSF3OS; C17orf33
• NCBI Protein Information: granulocyte colony-stimulating factor
• UniProt Protein Name: Granulocyte colony-stimulating factor
• UniProt Gene Name: CSF3
• UniProt Synonym Gene Names: C17orf33; GCSF; G-CSF
• UniProt Entry Name: CSF3_HUMAN

NCBI Description

The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes. The active protein is found extracellularly. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]

Uniprot Description

G-CSF: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes. Belongs to the IL-6 superfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide; Cytokine; Cell cycle regulation

Chromosomal Location of Human Ortholog: 17q11.2-q12

Cellular Component: extracellular space

Molecular Function: enzyme binding; growth factor activity; cytokine activity; granulocyte colony-stimulating factor receptor binding

Biological Process: positive regulation of myeloid cell differentiation; granulocyte differentiation; positive regulation of protein binding; multicellular organismal development; cytokine and chemokine mediated signaling pathway; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein kinase B signaling cascade; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of actin filament polymerization; positive regulation of cell proliferation; positive regulation of transcription factor import into nucleus; positive regulation of transcription from RNA polymerase II promoter; immune response