Mouse anti-Human YEATS4 Monoclonal Antibody | anti-YEATS4 antibody

YEATS4 (YEATS4, GAS41, YEATS domain-containing protein 4, Glioma-amplified sequence 41, NuMA-binding protein 1) (Azide free) (HRP)

Cat. Num. AAA6121608

• Gene Names: YEATS4; YAF9; GAS41; NUBI-1; 4930573H17Rik; B230215M10Rik
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Purified by Protein G Affinity Chromatography
• Synonyms: YEATS4; Monoclonal Antibody; YEATS4 (YEATS4; GAS41; YEATS domain-containing protein 4; Glioma-amplified sequence 41; NuMA-binding protein 1) (Azide free) (HRP); NuMA-binding protein 1; anti-YEATS4 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1,k
• Clone Number: 204CT4.7.2
• Purity/Purification: Purified by Protein G Affinity Chromatography
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with horseradish peroxidase (HRP).

• Applicable Applications for anti-YEATS4 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: ELISA: 1:1000; WB: 1:100-250; Applications are based on unconjugated antibody.
• Immunogen: YEATS4 Mab is generated from mouse immunized with YEATS4 recombinant protein.
• Conjugate: HRP
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(YEATS4 antibody western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the YEATS4 antibody detected the YEATS4 protein (arrow).)

Related Product Information for anti-YEATS4 antibody

The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors.

Product Categories/Family for anti-YEATS4 antibody

Antibodies; Cancer Markers

References

Heisel, S., et al. BMC Mol. Biol. 11, 53 (2010) Turner, S.T., et al. Hypertension 52(2):359-365(2008) Italiano, A., et al. Int. J. Cancer 122(10):2233-2241(2008) Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008) Park, J.H., et al. Mol. Cell. Biol. 26(11):4006-4016(2006)

NCBI and Uniprot Product Information

• NCBI GI #: 5729838
• NCBI GeneID: 8089
• NCBI Accession #: NP_006521.1
• NCBI GenBank Nucleotide #: NM_006530.2
• UniProt Accession #: O95619; Q9NQD0
• Molecular Weight: 26,499 Da
• NCBI Official Full Name: YEATS domain-containing protein 4
• NCBI Official Synonym Full Names: YEATS domain containing 4
• NCBI Official Symbol: YEATS4
• NCBI Official Synonym Symbols: YAF9; GAS41; NUBI-1; 4930573H17Rik; B230215M10Rik
• NCBI Protein Information: YEATS domain-containing protein 4; nuBI1; NuMA binding protein 1; nuMA-binding protein 1; glioma-amplified sequence 41; glioma-amplified sequence-41
• UniProt Protein Name: YEATS domain-containing protein 4
• Protein Family: YEATS domain-containing protein
• UniProt Gene Name: YEATS4
• UniProt Synonym Gene Names: GAS41; Gas41; NuBI-1; NuBI1
• UniProt Entry Name: YETS4_HUMAN

NCBI Description

The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors. [provided by RefSeq, Jul 2008]

Uniprot Description

YEATS4: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 12q13-q15

Cellular Component: nucleoplasm; NuA4 histone acetyltransferase complex; nuclear matrix; cytoplasm; nucleolus

Molecular Function: protein C-terminus binding; protein binding; DNA binding; structural constituent of cytoskeleton; transcription factor activity

Biological Process: mitosis; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; regulation of growth; positive regulation of transcription, DNA-dependent