Mouse anti-Human YEATS Domain Containing 4 Monoclonal Antibody | anti-YEATS4 antibody

YEATS Domain Containing 4 (YEATS4, 4930573H17Rik, B230215M10Rik, YAF9)

Cat. Num. AAA601691

• Gene Names: YEATS4; YAF9; GAS41; NUBI-1; 4930573H17Rik; B230215M10Rik
• Reactivity: Human
• Applications: Western Blot
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: YEATS Domain Containing 4; Monoclonal Antibody; YEATS Domain Containing 4 (YEATS4; 4930573H17Rik; B230215M10Rik; YAF9); Anti -YEATS Domain Containing 4 (YEATS4; anti-YEATS4 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 8C360
• Specificity: Recognizes human YEATS Domain Containing 4.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a sterile-filtered liquid in PBS, pH 7.4, 1% BSA, 0.05% sodium azide.

• Applicable Applications for anti-YEATS4 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.; Dilution: Western Blot: 1:1000-1:2000
• Immunogen: Partial sequence of recombinant full-length protein to human YEATS Domain Containing 4
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Testing Data

Related Product Information for anti-YEATS4 antibody

The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription.

Product Categories/Family for anti-YEATS4 antibody

Antibodies; Abs to Transcription Factors

NCBI and Uniprot Product Information

• NCBI GI #: 12654343
• NCBI GeneID: 8089
• UniProt Accession #: O95619; Q9NQD0
• Molecular Weight: 26,499 Da
• NCBI Official Full Name: YEATS domain containing 4
• NCBI Official Synonym Full Names: YEATS domain containing 4
• NCBI Official Symbol: YEATS4
• NCBI Official Synonym Symbols: YAF9; GAS41; NUBI-1; 4930573H17Rik; B230215M10Rik
• NCBI Protein Information: YEATS domain-containing protein 4; nuBI1; NuMA binding protein 1; nuMA-binding protein 1; glioma-amplified sequence 41; glioma-amplified sequence-41
• UniProt Protein Name: YEATS domain-containing protein 4
• Protein Family: YEATS domain-containing protein
• UniProt Gene Name: YEATS4
• UniProt Synonym Gene Names: GAS41
• UniProt Entry Name: YETS4_HUMAN

NCBI Description

The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors. [provided by RefSeq]

Uniprot Description

YEATS4: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 12q13-q15

Cellular Component: nucleoplasm; NuA4 histone acetyltransferase complex; nuclear matrix; cytoplasm; nucleolus

Molecular Function: protein C-terminus binding; protein binding; DNA binding; structural constituent of cytoskeleton; transcription factor activity

Biological Process: mitosis; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; regulation of growth