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Western Blot (WB) (Western Blot to detects VEGF4 in HDMEC cell lysate usingMBS6009969.)

Mouse anti-Human, Mouse VEGF4 Monoclonal Antibody | anti-VEGF4 antibody

VEGF4 (FIGF, VEGFD, Vascular endothelial growth factor D, c-Fos-induced growth factor) (MaxLight 550)

Gene Names
FIGF; VEGFD; VEGF-D
Reactivity
Human, Mouse
Applications
Western Blot
Purity
Purified by Protein G Affinity Chromatography
Synonyms
VEGF4; Monoclonal Antibody; VEGF4 (FIGF; VEGFD; Vascular endothelial growth factor D; c-Fos-induced growth factor) (MaxLight 550); FIGF; c-Fos-induced growth factor; anti-VEGF4 antibody
Ordering
For Research Use Only!
Host
Mouse
Reactivity
Human, Mouse
Clonality
Monoclonal
Isotype
IgG1
Clone Number
28AT743.288.48
Specificity
Recognizes human VEGF4. Species Crossreactivity: mouse
Purity/Purification
Purified by Protein G Affinity Chromatography
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.
Applicable Applications for anti-VEGF4 antibody
FLISA, Western Blot (WB)
Application Notes
Applications are based on unconjugated antibody.
Immunogen
Three KLH conjugated synthetic peptides corresponding to N-terminal, central, and C-terminal sequences of human VEGF4, UniProt Accession #O43915.
Conjugate
MaxLight550
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western Blot to detects VEGF4 in HDMEC cell lysate usingMBS6009969.)

Western Blot (WB) (Western Blot to detects VEGF4 in HDMEC cell lysate usingMBS6009969.)
Related Product Information for anti-VEGF4 antibody
The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C.
Product Categories/Family for anti-VEGF4 antibody
References
1. A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). Romero R, et al. Am J Obstet Gynecol, 2010 Jul 29. PMID 20673868.2. Clinical significance of vascular endothelial growth factors C and D and chemokine receptor CCR7 in gastric cancer. Deguchi K, et al. Anticancer Res, 2010 Jun. PMID 20651394. 3. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. Romero R, et al. Am J Obstet Gynecol, 2010 May. PMID 20452482. 4. New genetic associations detected in a host response study to hepatitis B vaccine. Davila S, et al. Genes Immun, 2010 Apr. PMID 20237496. 5. Neuroblastoma progression correlates with downregulation of the lymphangiogenesis inhibitor sVEGFR-2. Becker J, et al. Clin Cancer Res, 2010 Mar 1. PMID 20179233.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
40,444 Da
NCBI Official Full Name
vascular endothelial growth factor D preproprotein
NCBI Official Synonym Full Names
c-fos induced growth factor (vascular endothelial growth factor D)
NCBI Official Symbol
FIGF
NCBI Official Synonym Symbols
VEGFD; VEGF-D
NCBI Protein Information
vascular endothelial growth factor D
UniProt Protein Name
Vascular endothelial growth factor D
UniProt Gene Name
FIGF
UniProt Synonym Gene Names
VEGFD; VEGF-D; FIGF
UniProt Entry Name
VEGFD_HUMAN

NCBI Description

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus. [provided by RefSeq, Feb 2011]

Uniprot Description

VEGFD: Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. Belongs to the PDGF/VEGF growth factor family.

Protein type: Cytokine; Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: Xp22.31

Cellular Component: extracellular space; membrane; extracellular region

Molecular Function: protein homodimerization activity; growth factor activity; platelet-derived growth factor receptor binding; vascular endothelial growth factor receptor 3 binding; vascular endothelial growth factor receptor binding; chemoattractant activity

Biological Process: cell proliferation; platelet activation; platelet degranulation; positive chemotaxis; positive regulation of cell division; positive regulation of cell proliferation; angiogenesis; blood coagulation; vascular endothelial growth factor receptor signaling pathway; cell differentiation; induction of positive chemotaxis

Research Articles on VEGF4

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Product Notes

The VEGF4 figf (Catalog #AAA6210004) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The VEGF4 (FIGF, VEGFD, Vascular endothelial growth factor D, c-Fos-induced growth factor) (MaxLight 550) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's VEGF4 can be used in a range of immunoassay formats including, but not limited to, FLISA, Western Blot (WB). Applications are based on unconjugated antibody. Researchers should empirically determine the suitability of the VEGF4 figf for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "VEGF4, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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