Rabbit anti-Human ULBP2  Monoclonal Antibody | anti-ULBP2  antibody

Rabbit anti Human ULBP2  Monoclonal Antibody

Cat. Num. AAA2544342

• Gene Names: ULBP2; N2DL2; RAET1H; NKG2DL2; ALCAN-alpha
• Reactivity: Human
• Applications: Immunohistochemistry
• Synonyms: ULBP2 ; Monoclonal Antibody; Rabbit anti Human ULBP2 Monoclonal Antibody; anti-ULBP2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 246

• Applicable Applications for anti-ULBP2 antibody: Immunohistochemistry (IHC) Paraffin
• Application Notes: IHC-P: 1-10 mug/mL
• Immunogen: Recombinant Human ULBP2/N2DL-2 protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-ULBP2  antibody

NKG2D ligand 2, also known as N2DL-2, NKG2DL2, ALCAN-alpha, Retinoic acid early transcript 1H, UL16-binding protein 2, ULBP2 and N2DL2, is cell membrane protein which belongs to the MHC class I family. ULBP2/N2DL-2 is expressed in various types of cancer cell lines and in the fetus, but not in normal tissues. ULBP2/N2DL-2 is a ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway.

NCBI and Uniprot Product Information

• NCBI GI #: 37182452
• NCBI GeneID: 80328
• Molecular Weight: 27,368 Da
• NCBI Official Full Name: ULBP2
• NCBI Official Synonym Full Names: UL16 binding protein 2
• NCBI Official Symbol: ULBP2
• NCBI Official Synonym Symbols: N2DL2; RAET1H; NKG2DL2; ALCAN-alpha
• NCBI Protein Information: NKG2D ligand 2
• UniProt Protein Name: NKG2D ligand 2
• UniProt Gene Name: ULBP2
• UniProt Synonym Gene Names: N2DL2; RAET1H; N2DL-2; NKG2DL2
• UniProt Entry Name: N2DL2_HUMAN

NCBI Description

This gene encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activation of NK cells. The encoded protein undergoes further processing to generate the mature protein that is either anchored to membrane via a glycosylphosphatidylinositol moiety, or secreted. Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells. This gene is located in a cluster of multiple MHC class I-related genes on chromosome 6. [provided by RefSeq, Jul 2015]

Uniprot Description

ULBP2: Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis- Golgi apparatus so that it does not reach the cell surface. Belongs to the MHC class I family.

Protein type: Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 6q25

Cellular Component: anchored to plasma membrane; cell surface; extracellular space

Molecular Function: antigen binding; natural killer cell lectin-like receptor binding

Biological Process: antigen processing and presentation; natural killer cell activation; natural killer cell mediated cytotoxicity