Mouse anti-Human TS/Thymidylate Synthase Monoclonal Antibody | anti-TYMS antibody

Anti-TS/Thymidylate Synthase Antibody (clone 2B2)

Cat. Num. AAA2400620

• Gene Names: TYMS; TS; TMS; HST422
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry, Immunoprecipitation, Western Blot
• Purity: Purified from ascites by Protein A
• Synonyms: TS/Thymidylate Synthase; Monoclonal Antibody; Anti-TS/Thymidylate Synthase Antibody (clone 2B2); Mouse Monoclonal (IgG1) to Human TS/Thymidylate Synthase; TYMS; HST422; Thymidylate synthetase; TMS; TS; Thymidylate synthase; Tsase; anti-TYMS antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1, k
• Clone Number: 2B2
• Specificity: Human TYMS
• Purity/Purification: Purified from ascites by Protein A
• Form/Format: PBS, pH 7.4.
• Sequence Length: 313

• Applicable Applications for anti-TYMS antibody: ELISA (EIA), Immunohistochemistry (IHC) Paraffin, Immunoprecipitation (IP), Western Blot (WB)
• Application Notes: IHC-P: 5 ug/ml
• Immunogen: TYMS (AAH13919, 111 a.a. ~ 211 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C or lower.; Aliquot to avoid repeated freezing and thawing.

Immunohistochemistry (IHC)

(Anti-TYMS antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Immunohistochemistry (WB)

(Anti-TYMS antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Western Blot (WB)

Related Product Information for anti-TYMS antibody

Thymidylate synthase catalyzes the methylation of deoxyuridylate todeoxythymidylate using 5, 10-methylenetetrahydrofolate (methylene-THF) asa cofactor. This function maintains the dTMP (thymidine-5-primemonophosphate) pool critical for DNA replication and repair. the enzymehas been of interest as a target for cancer chemotherapeutic agents. Itis considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs.

NCBI and Uniprot Product Information

• NCBI GI #: 4507751
• NCBI GeneID: 7298
• NCBI Accession #: NP_001062.1
• NCBI GenBank Nucleotide #: NM_001071.2
• UniProt Accession #: P04818; Q8WYK3; Q8WYK4
• Molecular Weight: 26,140 Da
• NCBI Official Full Name: thymidylate synthase
• NCBI Official Synonym Full Names: thymidylate synthetase
• NCBI Official Symbol: TYMS
• NCBI Official Synonym Symbols: TS; TMS; HST422
• NCBI Protein Information: thymidylate synthase
• UniProt Protein Name: Thymidylate synthase
• UniProt Gene Name: TYMS
• UniProt Synonym Gene Names: TS; TS; TSase

NCBI Description

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017]

Uniprot Description

Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.