Rabbit anti-Human TREML2  Monoclonal Antibody | anti-TREML2  antibody

Rabbit anti Human TREML2  Monoclonal Antibody

Cat. Num. AAA2544272

• Gene Names: TREML2; TLT2; TLT-2; C6orf76; dJ238O23.1
• Reactivity: Human
• Applications: ELISA
• Synonyms: TREML2 ; Monoclonal Antibody; Rabbit anti Human TREML2 Monoclonal Antibody; anti-TREML2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 321

• Applicable Applications for anti-TREML2 antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human TREML2. The detection limit for Human TREML2 is approximately 0.00245 ng/well.
• Immunogen: Recombinant Human TREML2/TLT-2 protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-TREML2  antibody

Trem-like transcript 2 protein, also known as Triggering receptor expressed on myeloid cells-like protein 2, TREML2 and TLT2, is a single-pass type I  membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. TREML2 is detected in cultured B cells, T cell leukemia and monocyte leukemia. TREML2 is expressed constitutively on CD8 T-cells and induced on CD4 T-cells after activation. TREML2 is a cell surface receptor that may play a role in the innate and adaptive immune response. TREML2 acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation. Murine B7-H3 specifically bound to Triggering receptor expressed on myeloid cells (TREM)-like transcript 2 (TLT-2, TREML2). TREML2 was expressed on CD8 (+) T cells constitutively and on activated CD4 (+) T cells. Stimulation with B7-H3 transfectants preferentially up-regulated the proliferation and IFN-gamma production of CD8 (+) T cells. Transduction of TREML2 into T cells resulted in enhanced IL-2 and IFN-gamma production via interactions with B7-H3. There maybe a direct interaction between B7-H3 and TREML2 that preferentially enhances CD8 (+) T cell activation.

NCBI and Uniprot Product Information

• NCBI GI #: 170932501
• NCBI GeneID: 79865
• NCBI GenBank Nucleotide #: NM_024807.3
• Molecular Weight: 35,127 Da
• NCBI Official Full Name: trem-like transcript 2 protein
• NCBI Official Synonym Full Names: triggering receptor expressed on myeloid cells like 2
• NCBI Official Symbol: TREML2
• NCBI Official Synonym Symbols: TLT2; TLT-2; C6orf76; dJ238O23.1
• NCBI Protein Information: trem-like transcript 2 protein
• UniProt Protein Name: Trem-like transcript 2 protein
• UniProt Gene Name: TREML2
• UniProt Synonym Gene Names: C6orf76; TLT2; TLT-2
• UniProt Entry Name: TRML2_HUMAN

NCBI Description

TREML2 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties (Allcock et al., 2003 [PubMed 12645956]).[supplied by OMIM, Mar 2008]

Uniprot Description

TREML2: Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: cell surface; plasma membrane

Molecular Function: protein binding; receptor activity

Biological Process: regulation of immune response; T cell activation