Mouse anti-Human Toll-like Receptor 6 (TLR6) Monoclonal Antibody | anti-TLR6 antibody

Mouse Anti-Human TLR6-UNLB

Cat. Num. AAA670143

• Gene Names: TLR6; CD286
• Reactivity: Human
• Applications: ELISA
• Synonyms: Toll-like Receptor 6 (TLR6); Monoclonal Antibody; Mouse Anti-Human TLR6-UNLB; Mouse Anti-Human TLR6 - Purified; Unlabeled Antibody; Mouse Anti-Human Toll-like Receptor 6 (TLR6); anti-TLR6 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: Mouse IgG2a kappa
• Clone Number: 3B6
• Specificity: Human Toll-like Receptor 6 (TLR6); The Toll-like receptor (TLR) family is comprised of Type I transmembrane proteins characterized by an extracellular leucine-rich domain and a cytoplasmic tail that contains a conserved region call the Toll/IL-1 (TIR) domain. First discovered in Drosophila, TLRs recognize specific molecular patterns that are present in microbial components and respond to these components in order eliminate or limit invading microbes. To date, ten mammalian homologs of TLRs have been described. TLRs signal through adaptor molecules such as MyD88 leading to NF- kappa B activation, c-Jun N-terminal kinase activation (JNK), cytokine secretion and the inflammatory response. The amino acid sequence of human TLR6 is most similar to hTLR1 with 69% identity. TLR6 recognizes mycoplasmal macrophage-activating lipopeptide- 2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B. burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2.1-6
• Form/Format: Purified (UNLB) Antibody
• Sequence Length: 796

• Applicable Applications for anti-TLR6 antibody: ELISA
• Application Notes: ELISA Suggested Dilution: 1:3,000-1:5,000
• Characterization: To insure lot-to-lot consistency, each batch of product is tested by ELISA and/or flow cytometry to conform with the characteristics of a standard reference reagent.
• Preparation and Storage: The purified antibody (UNLB) is supplied as 0.1 mg purified immunoglobulin in 0.2 mL of 100 mM borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added. Store at 2- 8 degree C. ; Reagents are stable for the period shown on the label if stored as directed.

References

1. Hajjar, A.M., D.S. O'Mahony, A. Ozinsky, D.M. Underhill, A. Aderem, S.J. Klebanoff, and C.B. Wilson. 2001. J. Immunol. 166:15.
2. Takeuchi, O., T. Kawai, P.F. Muhlradt, M. Morr, J.D. Radolf, A. Zychlinsky, K. Takeda, and S. Akira. 2001. Int. Immunol. 13:933.
3. Bulut, Y., E. Faure, L. Thomas, O. Equils, and M. Arditi. 2001. J. Immunol. 167:987.
4. Akira, S., and K. Takeda. 2004. Nat. Rev. Immunol. 4:499.
5. Takeuchi, O. T. Kawai, H. Sanjo, N.G. Copeland, D.J. Gilbert, N.A. Jenkins, K. Takeda, and S. Akira. 1999. Gene 231:59.
6. Muzio, M., G. Gioacchino, S. Saccani, M. Lavrero, and A. Mantovani. 1998. J. Exp. Med. 187:2097.

NCBI and Uniprot Product Information

• NCBI GI #: 164708005
• NCBI GeneID: 10333
• UniProt Accession #: Q9Y2C9; B3Y640; B6CH35; B6RFS4; B6RFS5; Q2NKL3
• NCBI Official Full Name: toll-like receptor 6
• NCBI Official Synonym Full Names: toll-like receptor 6
• NCBI Official Symbol: TLR6
• NCBI Official Synonym Symbols: CD286
• NCBI Protein Information: toll-like receptor 6; OTTHUMP00000218187
• UniProt Protein Name: Toll-like receptor 6
• UniProt Entry Name: TLR6_HUMAN

NCBI Description

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.

Uniprot Description

TLR6: Participates in the innate immune response to Gram- positive bacteria and fungi. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. Belongs to the Toll-like receptor family.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4p14

Cellular Component: phagocytic vesicle membrane; integral to plasma membrane; plasma membrane

Molecular Function: transmembrane receptor activity; protein heterodimerization activity; receptor activity; diacylated lipoprotein binding

Biological Process: positive regulation of JNK activity; T-helper 1 type immune response; regulation of cytokine secretion; positive regulation of I-kappaB kinase/NF-kappaB cascade; detection of diacylated bacterial lipoprotein; positive regulation of interleukin-6 biosynthetic process; activation of NF-kappaB-inducing kinase; signal transduction; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; defense response to bacterium; toll-like receptor 6 signaling pathway; toll-like receptor signaling pathway; innate immune response; immune response; inflammatory response; toll-like receptor 4 signaling pathway