Mouse anti-Transfected Toll-like Receptor 3 Monoclonal Antibody | anti-TLR3 antibody

Anti-Toll-like Receptor 3 Antibody

Cat. Num. AAA9231157

• Gene Names: TLR3; CD283; IIAE2
• Reactivity: Transfected
• Applications: Western Blot
• Synonyms: Toll-like Receptor 3; Monoclonal Antibody; Anti-Toll-like Receptor 3 Antibody; CD283; CD283 antigen; IIAE2; TLR 3; Tlr3; TLR3_HUMAN; Toll Like Receptor 3; Toll-like receptor 3.; anti-TLR3 antibody

• Host: Mouse
• Reactivity: Transfected
• Clonality: Monoclonal
• Isotype: IgG2b
• Form/Format: Purified mouse monoclonal antibody in PBS (pH 7.4) containing with 0.03% Proclin300 and 50% glycerol.
• Sequence Length: 904

• Applicable Applications for anti-TLR3 antibody: Western Blot (WB)
• Application Notes: WB: 1:1000
• Cellular Location: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane. Early endosome
• Tissue Location: Expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors. TLR3 is the TLR that is expressed most strongly in the brain, especially in astrocytes, glia, and neurons.
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt

Western Blot (WB)

(Western blot detection of Toll-like Receptor 7 in CHO-K1 cell lysate (B)and CHO-K1 transfected by Toll-like Receptor 3 (A)cell lysate using Toll-like Receptor 3 mouse mAb (1:1000 diluted).Predicted band size: 50KDa.Observed band size:50KDa.)

Related Product Information for anti-TLR3 antibody

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response.

NCBI and Uniprot Product Information

• NCBI GI #: 4507531
• NCBI GeneID: 7098
• NCBI Accession #: NP_003256.1
• NCBI GenBank Nucleotide #: NM_003265
• UniProt Accession #: O15455; Q4VAL2; Q504W0; B2RAI7; B7Z7K0; E6Y0F0; E6Y0F1; E9PGH4
• Molecular Weight: 103829 Da
• NCBI Official Full Name: toll-like receptor 3
• NCBI Official Synonym Full Names: toll like receptor 3
• NCBI Official Symbol: TLR3
• NCBI Official Synonym Symbols: CD283; IIAE2
• NCBI Protein Information: toll-like receptor 3
• UniProt Protein Name: Toll-like receptor 3
• Protein Family: Toll-like receptor
• UniProt Gene Name: TLR3

NCBI Description

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

TLR3: a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. Most abundantly expressed in placenta and pancreas. Restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection. Acts via MyD88 and TRAF6, leading to the activation of NF-kappaB and the production of type I interferon.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 4q35.1

Cellular Component: cell surface; cytoplasm; endoplasmic reticulum membrane; endosome membrane; Golgi membrane; integral to plasma membrane; intracellular; lysosomal membrane

Molecular Function: double-stranded RNA binding; identical protein binding; protein binding; receptor activity

Biological Process: defense response to bacterium; defense response to virus; I-kappaB kinase/NF-kappaB cascade; I-kappaB phosphorylation; innate immune response; MyD88-independent toll-like receptor signaling pathway; negative regulation of MyD88-independent toll-like receptor signaling pathway; positive regulation of chemokine production; positive regulation of inflammatory response; positive regulation of interferon-alpha biosynthetic process; positive regulation of interferon-beta biosynthetic process; positive regulation of interferon-beta production; positive regulation of interferon-gamma biosynthetic process; positive regulation of interleukin-12 production; positive regulation of interleukin-6 production; positive regulation of interleukin-8 production; positive regulation of NF-kappaB import into nucleus; positive regulation of toll-like receptor signaling pathway; positive regulation of transcription from RNA polymerase II promoter; positive regulation of tumor necrosis factor production; response to exogenous dsRNA; signal transduction; toll-like receptor 3 signaling pathway; toll-like receptor signaling pathway

Disease: Human Immunodeficiency Virus Type 1, Susceptibility To