Structure
BRD0705, Inhibitor
BRD0705
Purity
>98% (HPLC)
Synonyms
BRD0705; BRD-0705; BRD 0705; inhibitor
Purity/Purification
>98% (HPLC)
Target
GSK-3
Receptor
GSK-3
Chemical Name
(S)-4-ethyl-7, 7-dimethyl-4-phenyl-2, 4, 6, 7, 8, 9-hexahydro-5H-pyrazolo[3, 4-b]quinolin-5-one
Molecular Formula
C20H23N3O
CAS Number
2056261-41-5
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for BRD0705, inhibitor
BRD0705 (BRD-0705) is a potent, paralog-selective GSK3alpha inhibitor with IC50 of 66nM, 8-fold selectivity over GSK3beta (IC50=515nM); displays excellent selectivity in a penal of 311 kinases, the CDK family of CDK2, CDK3 and CDK5) are most potently inhibited with IC50 of 6.87, 9.74 and 9.20uM (87-, 123-, and 116-fold selectivity relative to GSK3alpha); inhibits GSK3alpha kinase function, impairs GSK3alpha Tyr279 phosphorylation in a time- and concentration-dependent manner without affecting GSK3beta Tyr216 phosphorylation, and does not stabilize beta-catenin, induces myeloid differentiation and impairs colony formation in AML cells, with no apparent effect on normal hematopoietic cells; impairs leukemia initiation and prolongs survival in AML mouse models.
Product Categories/Family for BRD0705, inhibitor
References
1. Wagner FF, et al. Sci Transl Med. 2018 Mar 7; 10 (431). pii: eaam8460.
2. Cancer Discov. 2018 Mar 16. doi: 10.1158/2159-8290.CD-RW2018-046.
2. Cancer Discov. 2018 Mar 16. doi: 10.1158/2159-8290.CD-RW2018-046.
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Product Notes
The BRD0705 (Catalog #AAA3603195) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "BRD0705, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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