Mouse anti-Human TLE3 Monoclonal Antibody | anti-TLE3 antibody

TLE3 Mouse Monoclonal

Cat. Num. AAA7604956

• Gene Names: TLE3; ESG; ESG3; GRG3; HsT18976
• Reactivity: Human
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunoprecipitation
• Purity: >=95% as determined by SDS-PAGE; Protein A+G purification
• Synonyms: TLE3; Monoclonal Antibody; TLE3 Mouse Monoclonal; anti-TLE3 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Purity/Purification: >=95% as determined by SDS-PAGE; Protein A+G purification
• Form/Format: Liquid
• Sequence Length: 699

• Applicable Applications for anti-TLE3 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)
• Immunogen: Transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human breast cancer slide using MBS7604956 (TLE3 Antibody) at dilution of 1:50)

Western Blot (WB)

(HEK-293 cells were subjected to SDS PAGE followed by western blot with MBS7604956 (TLE3 antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 545688925
• NCBI GeneID: 7090
• NCBI Accession #: NP_001269911.1
• NCBI GenBank Nucleotide #: NM_001282982.1
• Molecular Weight: 82,279 Da
• NCBI Official Full Name: transducin-like enhancer protein 3 isoform g
• NCBI Official Synonym Full Names: transducin like enhancer of split 3
• NCBI Official Symbol: TLE3
• NCBI Official Synonym Symbols: ESG; ESG3; GRG3; HsT18976
• NCBI Protein Information: transducin-like enhancer protein 3
• UniProt Protein Name: Transducin-like enhancer protein 3
• Protein Family: Transducin-like enhancer protein
• UniProt Gene Name: TLE3
• UniProt Synonym Gene Names: KIAA1547; ESG3
• UniProt Entry Name: TLE3_HUMAN

NCBI Description

This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]

Uniprot Description

Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES ().