Mouse anti-Human, Mouse TIMM44 Monoclonal Antibody | anti-TIMM44 antibody

TIMM44 Monoclonal Antibody

Cat. Num. AAA2542237

• Gene Names: TIMM44; TIM44
• Reactivity: Human, Mouse
• Applications: Western Blot, Immunohistochemistry, ELISA
• Purity: Protein G purification
• Synonyms: TIMM44; Monoclonal Antibody; TIMM44 Monoclonal Antibody; DKFZp686H05241; MIMT44; Mitochondrial inner membrane translocase; TIM44; Translocase of inner mitochondrial membrane 44; Translocase of inner mitochondrial membrane 44 homolog (yeast); anti-TIMM44 antibody

• Host: Mouse
• Reactivity: Human, Mouse
• Clonality: Monoclonal
• Isotype: IgG2c
• Clone Number: 116
• Purity/Purification: Protein G purification
• Concentration: 1mg/mL (varies by lot)
• Sequence Length: 452

• Applicable Applications for anti-TIMM44 antibody: Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
• Application Notes: WB: 1:500-1:5000; IHC: 1:20-1:200
• Immunogen: Fusion protein of TIMM44
• Buffer: PBS with 0.02% sodium azide, 50% glycerol, PH7.3
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Avoid freeze / thaw cycles.

Western Blot (WB)

(Western Blot analysis of HeLa cells using TIMM44 Monoclonal Antibody at dilution of 1:1000)

Related Product Information for anti-TIMM44 antibody

This gene encodes a peripheral membrane protein associated with the mitochondrial inner membrane translocase, which functions in the import of proteins across the mitochondrial inner membrane and into the mitochondrial matrix. The encoded protein mediates binding of mitochondrial heat shock protein 70 to the translocase of inner mitochondrial membrane 23 (TIM23) complex. Expression of this gene is upregulated in kidney in a mouse model of diabetes. A mutation in this gene is associated with familial oncocytic thyroid carcinoma. TIMM44 (Translocase Of Inner Mitochondrial Membrane 44) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Mitochondrial protein import. GO annotations related to this gene include chaperone binding and P-P-bond-hydrolysis-driven protein transmembrane transporter activity.

Product Categories/Family for anti-TIMM44 antibody

Metabolism

NCBI and Uniprot Product Information

• NCBI GI #: 33636719
• NCBI GeneID: 10469
• NCBI Accession #: NP_006342.2
• NCBI GenBank Nucleotide #: NM_006351.3
• UniProt Accession #: O43615; Q8N193; A8K0R9; D6W664
• Molecular Weight: Calculated: 51kDa; Observed: 45kDa
• NCBI Official Full Name: mitochondrial import inner membrane translocase subunit TIM44
• NCBI Official Synonym Full Names: translocase of inner mitochondrial membrane 44
• NCBI Official Symbol: TIMM44
• NCBI Official Synonym Symbols: TIM44
• NCBI Protein Information: mitochondrial import inner membrane translocase subunit TIM44
• UniProt Protein Name: Mitochondrial import inner membrane translocase subunit TIM44
• Protein Family: Mitochondrial import inner membrane translocase
• UniProt Gene Name: TIMM44
• UniProt Synonym Gene Names: MIMT44; TIM44

NCBI Description

This gene encodes a peripheral membrane protein associated with the mitochondrial inner membrane translocase, which functions in the import of proteins across the mitochondrial inner membrane and into the mitochondrial matrix. The encoded protein mediates binding of mitochondrial heat shock protein 70 to the translocase of inner mitochondrial membrane 23 (TIM23) complex. Expression of this gene is upregulated in kidney in a mouse model of diabetes. A mutation in this gene is associated with familial oncocytic thyroid carcinoma. [provided by RefSeq, Jul 2016]

Uniprot Description

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source.