anti-Mouse TIM-4 Monoclonal Antibody | anti-TIM-4 antibody
TIM-4, Mouse, mAb Kat5-18, FITC
Gene Names
TIMD4; TIM4; SMUCKLER
Reactivity
Mouse
Applications
Flow Cytometry, Functional Assay, Immunofluorescence
Synonyms
TIM-4; Monoclonal Antibody; Mouse; mAb Kat5-18; FITC; TIMD4; T-cell immunoglobulin and mucin domain containing molecule; anti-TIM-4 antibody
Host
Armenian Hamster
Reactivity
Mouse
Clonality
Monoclonal
Isotype
IgG
Clone Number
Kat5-18
Form/Format
1 ml (100 ug/ml) 0.2 um filtered FITC conjugated antibody solution in PBS, containing 0.1% bovine serum albumin and 0.02% sodium azide.
Sequence Length
378
Applicable Applications for anti-TIM-4 antibody
Flow Cytometry (FC/FACS), Functional Studies (FS), Immuno Assay (IA), Immunofluorescence (IF)
Application Notes
The typical starting working dilution is 1:50.
Immunogen
Mouse peritoneal cells
Conjugate
FITC
Preparation and Storage
Store at 4 degree C. Under recommended storage conditions, product is stable for one year.
Related Product Information for anti-TIM-4 antibody
The monoclonal antibody Kat5-18 recognizes T-cell immunoglobulin and mucin domain containing molecule (TIMD-4, also called TIM-4). TIMD-4 is a type I transmembrane protein belonging to the immunoglobulin superfamily, containing one Ig-like V-type (immunoglobulin-like) domain. TIMD-4 is expressed in Mac1+ cells in spleen, lymph nodes and fetal liver. TIMD-4 binds apoptotic cells by recognizing phosphatidylserine via its immunoglobulin domain. TIMD-4 in fibroblasts enhanced their ability to engulf apoptotic cells. TIMD-4 is involved in regulating T-cell proliferation and lymphotoxin signaling. TIMD-4 and TIMD-1 are phosphatidylserine receptors for the engulfment of apoptotic cells, and are also involved in intracellular signaling in which exosomes are involved. The monoclonal antibody Kat5-18 blocks the engulfment of apoptotic cells by thymic macrophages.
References
Miyanishi, M et al; Identification of Tim4 as a phosphatidylserine receptor. Nature 2007, 450: 435
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
38,536 Da
NCBI Official Full Name
T-cell immunoglobulin and mucin domain-containing protein 4 isoform 1
NCBI Official Synonym Full Names
T-cell immunoglobulin and mucin domain containing 4
NCBI Official Symbol
TIMD4
NCBI Official Synonym Symbols
TIM4; SMUCKLER
NCBI Protein Information
T-cell immunoglobulin and mucin domain-containing protein 4
UniProt Protein Name
T-cell immunoglobulin and mucin domain-containing protein 4
UniProt Gene Name
TIMD4
UniProt Synonym Gene Names
TIM4; TIMD-4; TIM-4
Uniprot Description
TIM-4: Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1. Belongs to the immunoglobulin superfamily. TIM family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 5q33.3
Research Articles on TIM-4
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Product Notes
The TIM-4 timd4 (Catalog #AAA584714) is an Antibody produced from Armenian Hamster and is intended for research purposes only. The product is available for immediate purchase. The TIM-4, Mouse, mAb Kat5-18, FITC reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's TIM-4 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS), Functional Studies (FS), Immuno Assay (IA), Immunofluorescence (IF). The typical starting working dilution is 1:50. Researchers should empirically determine the suitability of the TIM-4 timd4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TIM-4, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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