Mouse anti-Human Tenascin Monoclonal Antibody | anti-TNC antibody

Tenascin, NT (Cytotactin, Tenascin C, Glioma associated Extracellular Matrix Antigen, GMEM, Hexabrachion)

Cat. Num. AAA649247

• Gene Names: TNC; GP; JI; TN; HXB; GMEM; TN-C; DFNA56; 150-225
• Reactivity: Human
• Applications: Western Blot, Immunohistochemistry
• Purity: Affinity Purified; Purified by Protein A chromatography.
• Synonyms: Tenascin; Monoclonal Antibody; NT (Cytotactin; Tenascin C; Glioma associated Extracellular Matrix Antigen; GMEM; Hexabrachion); Anti -Tenascin; anti-TNC antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1,k
• Clone Number: 2Q567
• Specificity: Recognizes an epitope contained within the globular domain in the amino terminal region of human tenascin arms.
• Purity/Purification: Affinity Purified; Purified by Protein A chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide.

• Applicable Applications for anti-TNC antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Immunohistochemistry and Western Blot.
• Immunogen: Synthetic peptide to human Tenascin located in the N-terminal region.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-TNC antibody

Tenascin is a large glycoprotein that forms disulfide-linked hexamers. Tenascin is made up of a series of repeated structural domains including EGF-like repeats, fibronectin type III repeats, and a region homologous to fibrinogen. Splice variants of tenascin differ in their number of fibronectin type III repeats. Tenascin is expressed in distinctive spatial and temporal patterns in most embryonic tissues at sites of tissue remodeling and cell migration. There is little expression of tenascin in adult tissues except, again, at sites of tissue remodeling and cell migration such as surrounding tumors, in healing wounds, and in branching or damaged blood vessels.

Product Categories/Family for anti-TNC antibody

Antibodies; Abs to Extracellular Matrix Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 153946395
• NCBI GeneID: 3371
• NCBI Accession #: NP_002151.2
• NCBI GenBank Nucleotide #: NM_002160.3
• UniProt Accession #: P24821; Q14583; Q15567; Q5T7S3; C9IYT7; C9J575; C9J6D9; C9J848
• Molecular Weight: 240,853 Da
• NCBI Official Full Name: tenascin
• NCBI Official Synonym Full Names: tenascin C
• NCBI Official Symbol: TNC
• NCBI Official Synonym Symbols: GP; JI; TN; HXB; GMEM; TN-C; DFNA56; 150-225
• NCBI Protein Information: tenascin; GP 150-225; cytotactin; neuronectin; myotendinous antigen; hexabrachion (tenascin); tenascin-C isoform 14/AD1/16; glioma-associated-extracellular matrix antigen
• UniProt Protein Name: Tenascin
• Protein Family: Tenascin
• UniProt Gene Name: TNC
• UniProt Synonym Gene Names: HXB; TN; TN-C
• UniProt Entry Name: TENA_HUMAN

NCBI Description

This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011]

Uniprot Description

Function: Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6.

Subunit structure: Homohexamer; disulfide-linked. A homotrimer may be formed in the triple coiled-coil region and may be stabilized by disulfide rings at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. Interacts with CSPG4. Ref.8

Subcellular location: Secreted › extracellular space › extracellular matrix.

Induction: By TGFB1.

Sequence similarities: Belongs to the tenascin family.Contains 15 EGF-like domains.Contains 1 fibrinogen C-terminal domain.Contains 15 fibronectin type-III domains.