Mouse anti-Human TBX21 Monoclonal Antibody | anti-TBX21 antibody

TBX21 (T-box Transcription Factor TBX21, T-box Protein 21, Transcription Factor TBLYM, T-cell-specific T-box Transcription Factor T-bet, TBET, TBLYM) (Azide Free)

Cat. Num. AAA632922

• Gene Names: TBX21; TBET; T-PET; T-bet; TBLYM
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Purified; Purified by ammonium sulfate precipitation.
• Synonyms: TBX21; Monoclonal Antibody; TBX21 (T-box Transcription Factor TBX21; T-box Protein 21; Transcription Factor TBLYM; T-cell-specific T-box Transcription Factor T-bet; TBET; TBLYM) (Azide Free); Anti -TBX21 (T-box Transcription Factor TBX21; anti-TBX21 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2a,k
• Clone Number: 11C854
• Specificity: Recognizes human TBX21.
• Purity/Purification: Purified; Purified by ammonium sulfate precipitation.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. Azide free.

• Applicable Applications for anti-TBX21 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: Western Blot: 1:500-1:1000; ELISA: 1ug/ml-3ng/ml
• Immunogen: Partial recombinant protein corresponding to aa387-486 of human TBX21 with a GST tag. The MW of the GST tag alone is 26kD.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-TBX21 antibody

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells

Product Categories/Family for anti-TBX21 antibody

Antibodies; Abs to Transcription Factors

NCBI and Uniprot Product Information

• NCBI GI #: 7019549
• NCBI GeneID: 30009
• NCBI Accession #: NP_037483.1
• NCBI GenBank Nucleotide #: NM_013351.1
• UniProt Accession #: Q53EK5; Q9UL17
• Molecular Weight: 58,302 Da
• NCBI Official Full Name: T-box transcription factor TBX21
• NCBI Official Synonym Full Names: T-box 21
• NCBI Official Symbol: TBX21
• NCBI Official Synonym Symbols: TBET; T-PET; T-bet; TBLYM
• NCBI Protein Information: T-box transcription factor TBX21; T-box protein 21; T-box expressed in T cells; transcription factor TBLYM; T-cell-specific T-box transcription factor T-bet
• UniProt Protein Name: T-box 21 variant
• Protein Family: T-box transcription factor
• UniProt Entry Name: Q53EK5_HUMAN

NCBI Description

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq]

Uniprot Description

TBX21: Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs. T-cell specific.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 17q21.32

Cellular Component: cell soma; nucleus

Molecular Function: transcription factor activity

Biological Process: positive regulation of isotype switching to IgG isotypes; regulation of transcription, DNA-dependent; transcription, DNA-dependent; response to virus; multicellular organismal development; positive regulation of transcription, DNA-dependent; T cell differentiation

Disease: Asthma, Nasal Polyps, And Aspirin Intolerance