Western Blot (WB)
(CNOT6 Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the CNOT6 antibody detected the CNOT6 protein (arrow).)
Rabbit anti-Human CNOT6 Polyclonal Antibody | anti-CNOT6 antibody
CNOT6, CT (CNOT6, CCR4, KIAA1194, CCR4-NOT transcription complex subunit 6, CCR4 carbon catabolite repression 4-like, Carbon catabolite repressor protein 4 homolog, Cytoplasmic deadenylase)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Western Blot (WB)
(CNOT6 Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the CNOT6 antibody detected the CNOT6 protein (arrow).)
Western Blot (WB)
(CNOT6 Antibody (C-term) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the CNOT6 antibody detected the CNOT6 protein (arrow).)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a subunit of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substates. [provided by RefSeq, Jul 2008]
Uniprot Description
CNOT6: Poly(A) nuclease involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. Has 3'-5' RNase activity. The CCR4-NOT complex functions as general transcription regulation complex. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Belongs to the CCR4/nocturin family.
Protein type: Hydrolase; EC 3.1.13.4
Chromosomal Location of Human Ortholog: 5q35.3
Cellular Component: membrane; nucleus; cytosol; CCR4-NOT complex
Molecular Function: protein binding; poly(A)-specific ribonuclease activity; exoribonuclease activity; RNA binding; metal ion binding
Biological Process: regulation of translation; poly(A) tail shortening; transcription, DNA-dependent; regulation of transcription, DNA-dependent; positive regulation of cell proliferation; gene expression; miRNA-mediated gene silencing; mRNA catabolic process, deadenylation-dependent decay
Research Articles on CNOT6
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Product Notes
The CNOT6 cnot6 (Catalog #AAA6002560) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CNOT6, CT (CNOT6, CCR4, KIAA1194, CCR4-NOT transcription complex subunit 6, CCR4 carbon catabolite repression 4-like, Carbon catabolite repressor protein 4 homolog, Cytoplasmic deadenylase) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CNOT6 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in Western Blot, ELISA Dilution: ELISA: 1:1,000 Western Blot: 1:100-500. Researchers should empirically determine the suitability of the CNOT6 cnot6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CNOT6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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