Testing Data
(Figure 1: Immunohistochemistry on paraffin section of human lung
)
anti-Human TBX-2 Monoclonal Antibody | anti-tbx-2 antibody
Mouse anti TBX-2
Reactivity
Human
Applications
Immunoprecipitation, Western Blot
Synonyms
TBX-2; Monoclonal Antibody; Mouse anti TBX-2; anti-tbx-2 antibody
Host
Mouse (Balb/c)
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1
Clone Number
4D6
Form/Format
Each vial contains 100 ul 1 mg/ml purified monoclonal antibody in PBS containing 0.09% sodium azide.
Applicable Applications for anti-tbx-2 antibody
Immunoprecipitation (IP), Western Blot (WB)
Application Notes
4D6 is useful for immunoprecipitation and western blot. Optimal antibody dilution should be determined by titRation.
Source Note
4D6 is a Mouse monoclonal IgG1 antibody derived by fusion of SP2/0 Mouse myeloma cells with spleen cells from a BALB/c Mouse immunized with a GST fusion protein corresponding to residues 554-702 of Human TBX2.
Preparation and Storage
Store at 4 degree C, or in small aliquots at -20 degree C.
Testing Data
(Figure 1: Immunohistochemistry on paraffin section of human lung )
Testing Data
(Figure 1: Immunohistochemistry on paraffin section of human lung
)
Related Product Information for anti-tbx-2 antibody
T-box transcription factor TBX2 is a protein that in Humans is encoded by the TBX2 gene and with subcellulair loCation in the nucleus. This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the Human homolog of Mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indiCate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene. In melanocytic cell types, expression of the T-box 2 gene is regulated by the Microphthalmia-associated transcription factor The oncogene TBX2 is a coopeRating factor in transformation of pocket protein deficient MEFs. TBX2 downregulates the p53/p21CIP1 pathway both in wild-type and pocket protein deficient MEFs. Tissue specificity: expressed primarily in adult in kidney, lung, and placenta. Weak expression in heart and ovary.
Product Categories/Family for anti-tbx-2 antibody
References
Jacqueline J.L. Jacobs, Petra Keblusek, Els Robanus-Maandag, Petra Kristel, Merel Lingbeek, Petra M. Nederlof, Tibor van Welsem, Marc J. van de Vijver, Eugene Y. Koh, George Q. Daley & Maarten van Lohuizen. Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19ARF) and is amplified in a subset of Human breast cancers. Nat. Genet., 26: 291-9 (2000).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Official Full Name
T-box protein 2
NCBI Official Symbol
tbx-2
NCBI Protein Information
Protein TBX-2
Protein Family
Research Articles on tbx-2
Similar Products
Product Notes
The tbx-2 (Catalog #AAA570233) is an Antibody produced from Mouse (Balb/c) and is intended for research purposes only. The product is available for immediate purchase. The Mouse anti TBX-2 reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TBX-2 can be used in a range of immunoassay formats including, but not limited to, Immunoprecipitation (IP), Western Blot (WB). 4D6 is useful for immunoprecipitation and western blot. Optimal antibody dilution should be determined by titRation. Researchers should empirically determine the suitability of the tbx-2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TBX-2, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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