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Western Blot (WB) (Western Blot detection of TBLR1 antibody in Mouse brain, Mouse heart&K562 cell lysates using TBLR1 antibody (1:1000 diluted).)

Mouse anti-Human, Mouse TBLR1 Monoclonal Antibody | anti-TBLR1 antibody

TBLR1 Monoclonal Antibody

Gene Names
TBL1XR1; C21; DC42; IRA1; MRD41; TBLR1
Reactivity
Human, Mouse
Applications
Western Blot, Immunohistochemistry, Immunocytochemistry
Purity
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Synonyms
TBLR1; Monoclonal Antibody; TBLR1 Monoclonal Antibody; F-box-like/WD repeat-containing protein TBL1XR1; Nuclear receptor corepressor/HDAC3 complex subunit TBLR1; TBL1-related protein 1; Transducin beta-like 1X-related protein 1; TBL1XR1; IRA1; anti-TBLR1 antibody
Ordering
For Research Use Only!
Host
Mouse
Reactivity
Human, Mouse
Clonality
Monoclonal
Specificity
This antibody detects endogenous levels of TBLR1 and does not cross-react with related proteins
Purity/Purification
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Form/Format
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Sequence Length
514
Applicable Applications for anti-TBLR1 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
Application Notes
WB: 1:1000
ICC: 1:50-200
IHC: 1:50-500
Immunogen
Recombinant full length Human TBLR1.
Preparation and Storage
Store at 4 degree C short term.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot detection of TBLR1 antibody in Mouse brain, Mouse heart&K562 cell lysates using TBLR1 antibody (1:1000 diluted).)

Western Blot (WB) (Western Blot detection of TBLR1 antibody in Mouse brain, Mouse heart&K562 cell lysates using TBLR1 antibody (1:1000 diluted).)

Immunohistochemistry (IHC)

(IHC of paraffin-embedded huma breast cancer using anti- TBLR1 diluted 1/500-1/1000.)

Immunohistochemistry (IHC) (IHC of paraffin-embedded huma breast cancer using anti- TBLR1 diluted 1/500-1/1000.)

Immunocytochemistry (ICC)

(Immunocytochemistry of HeLa cells using anti- TBLR1 antibody diluted 1:150.)

Immunocytochemistry (ICC) (Immunocytochemistry of HeLa cells using anti- TBLR1 antibody diluted 1:150.)
Related Product Information for anti-TBLR1 antibody
F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, th ereby allowing cofactor exchange, and transcription activation.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
Predicted Band Size: 60KDa
Observed Band Size: 60Kda
NCBI Official Full Name
F-box-like/WD repeat-containing protein TBL1XR1 isoform 1
NCBI Official Synonym Full Names
TBL1X receptor 1
NCBI Official Symbol
TBL1XR1
NCBI Official Synonym Symbols
C21; DC42; IRA1; MRD41; TBLR1
NCBI Protein Information
F-box-like/WD repeat-containing protein TBL1XR1
UniProt Protein Name
F-box-like/WD repeat-containing protein TBL1XR1
UniProt Gene Name
TBL1XR1
UniProt Synonym Gene Names
IRA1; TBLR1
UniProt Entry Name
TBL1R_HUMAN

NCBI Description

This gene is a member of the WD40 repeat-containing gene family and shares sequence similarity with transducin (beta)-like 1X-linked (TBL1X). The protein encoded by this gene is thought to be a component of both nuclear receptor corepressor (N-CoR) and histone deacetylase 3 (HDAC 3) complexes, and is required for transcriptional activation by a variety of transcription factors. Mutations in these gene have been associated with some autism spectrum disorders, and one finding suggests that haploinsufficiency of this gene may be a cause of intellectual disability with dysmorphism. Mutations in this gene as well as recurrent translocations involving this gene have also been observed in some tumors. [provided by RefSeq, Mar 2016]

Research Articles on TBLR1

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Product Notes

The TBLR1 tbl1xr1 (Catalog #AAA3014251) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The TBLR1 Monoclonal Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's TBLR1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC). WB: 1:1000 ICC: 1:50-200 IHC: 1:50-500. Researchers should empirically determine the suitability of the TBLR1 tbl1xr1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TBLR1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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