Testing Data
(1:1000 dilution of this antibody detected TBLR1 on 40ug of cell lysates)
Mouse TBLR1 Monoclonal Antibody | anti-TBLR1 antibody
TBLR1 Monoclonal Antibody
Testing Data
(1:1000 dilution of this antibody detected TBLR1 on 40ug of cell lysates)
Testing Data
(1:1000 dilution of this antibody detected TBLR1 on 40ug of cell lysates)
Testing Data
(HeLa cells using anti- TBLR1 antibody diluted 1:150)
Testing Data
(HeLa cells using anti- TBLR1 antibody diluted 1:150)
Immunohistochemistry (IHC)
(Paraffin-- embedded huma breast cancer using anti- TBL1XR1 diluted 1:50-1:100)
Immunohistochemistry (IHC)
(Paraffin-- embedded huma breast cancer using anti- TBL1XR1 diluted 1:50-1:100)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene has sequence similarity with members of the WD40 repeat-containing protein family. The WD40 group is a large family of proteins, which appear to have a regulatory function. It is believed that the WD40 repeats mediate protein-protein interactions and members of the family are involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation. [provided by RefSeq, Jul 2008]
Uniprot Description
TBL1XR1: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1XR1, CORO2A and GPS2. Probable component of some E3 ubiquitin ligase complex. Interacts with histones H2B and H4. Ubiquitous. Belongs to the WD repeat EBI family.
Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 3q26.32
Cellular Component: nucleoplasm; transcriptional repressor complex; spindle microtubule; histone deacetylase complex; nucleus
Molecular Function: protein binding; histone binding; beta-catenin binding; protein N-terminus binding; transcription corepressor activity
Biological Process: proteasomal ubiquitin-dependent protein catabolic process; Notch signaling pathway; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; histone deacetylation; positive regulation of transcription from RNA polymerase II promoter; cellular lipid metabolic process; Wnt receptor signaling pathway through beta-catenin; negative regulation of transcription from RNA polymerase II promoter
Research Articles on TBLR1
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Product Notes
The TBLR1 tbl1xr1 (Catalog #AAA9400460) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The TBLR1 Monoclonal Antibody reacts with Human, Mouse, Rat, Porcine, Dog and may cross-react with other species as described in the data sheet. AAA Biotech's TBLR1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC). Western blotting: 1:1000. Researchers should empirically determine the suitability of the TBLR1 tbl1xr1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TBLR1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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