Mouse anti-Human Tachykinin-3 Monoclonal Antibody | anti-TAC3 antibody

Tachykinin-3 (ZNEUROK1, Neurokinin B, TAC3, NKNB)

Cat. Num. AAA606546

• Gene Names: TAC3; NKB; NKNB; PRO1155; ZNEUROK1
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by affinity chromatography.
• Synonyms: Tachykinin-3; Monoclonal Antibody; Tachykinin-3 (ZNEUROK1; Neurokinin B; TAC3; NKNB); Anti -Tachykinin-3 (ZNEUROK1; anti-TAC3 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Clone Number: 9G451
• Specificity: Recognizes human Tachykinin.
• Purity/Purification: Affinity Purified; Purified by affinity chromatography.
• Form/Format: Supplied as a lyophilized powder from PBS, pH 7.2. Reconstitute with 100ul sterile ddH2O.

• Applicable Applications for anti-TAC3 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.
• Immunogen: Recombinant human Tachykinin with GST tag.
• Preparation and Storage: Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile 40-50% glycerol, ddH2O. Reconstituted product is stable for 12 months at -20 degree C. Aliquot and store at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Western Blot (WB)

(Western blot detection of recombinant GST tagged human Tachykinin-3.)

ELISA (EIA)

(Sandwich ELISA using the anti-Tachykinin-3 antibody as a capture antibody. The detection limit for GST tagged recombinant Tachykinin-3 is 0.1 ng/ml.)

Related Product Information for anti-TAC3 antibody

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract many smooth muscles. Tachykinin-3 is a secreted protein and its expression during pregnancy is confined to the outer syncytiotophoblast of the placenta. Plasma concentrations of Tachykinin-3 are grossly elevated in pregnancy-induced hypertension and pre-eclampsia.

Product Categories/Family for anti-TAC3 antibody

Antibodies; Abs to Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 295849290
• NCBI GeneID: 6866
• NCBI Accession #: NP_001171525.1
• NCBI GenBank Nucleotide #: NM_001178054.1
• UniProt Accession #: Q2UVB8; Q7Z4W6; Q9UHF0
• Molecular Weight: 2,559 Da
• NCBI Official Full Name: tachykinin-3 isoform 2 preproprotein
• NCBI Official Synonym Full Names: tachykinin 3
• NCBI Official Symbol: TAC3
• NCBI Official Synonym Symbols: NKB; NKNB; PRO1155; ZNEUROK1
• NCBI Protein Information: tachykinin-3; neuromedin K; OTTHUMP00000211122; OTTHUMP00000211123; OTTHUMP00000211124; OTTHUMP00000211125; OTTHUMP00000211126; OTTHUMP00000211127; OTTHUMP00000211128; OTTHUMP00000211129; OTTHUMP00000211130; gamma tachykinin 3; preprotachykinin B
• UniProt Protein Name: Neurokinin-B protein
• Protein Family: Tachykinin
• UniProt Gene Name: TAC3
• UniProt Entry Name: Q2UVB8_HUMAN

NCBI Description

This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded protein is primarily expressed in the central and peripheral nervous system and functions as a neurotransmitter. This protein is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternate splicing results in multiple transcript variants. [provided by RefSeq]

Uniprot Description

TAC3: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Belongs to the tachykinin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 12q13.3

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; receptor binding

Biological Process: tachykinin signaling pathway; neuropeptide signaling pathway; female pregnancy

Disease: Hypogonadotropic Hypogonadism 10 With Or Without Anosmia