Mouse TAB1 Monoclonal Antibody | anti-TAB1 antibody

TAB1(N-term) Monoclonal Antibody

Cat. Num. AAA9400139

• Gene Names: TAB1; 3'-Tab1; MAP3K7IP1
• Reactivity: Human, Dog, Mouse, Porcine, Rat
• Applications: Western Blot
• Purity: Purified by antigen-affinity chromatography.
• Synonyms: TAB1; Monoclonal Antibody; TAB1(N-term) Monoclonal Antibody; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 TAK1-binding protein 1 transforming growth factor beta-activated kinase-binding protein 1 mitogen-activated protein kinase kinase kinase 7-interacting protein 1; anti-TAB1 antibody

• Host: Mouse
• Reactivity: Human, Dog, Mouse, Porcine, Rat
• Clonality: Monoclonal
• Purity/Purification: Purified by antigen-affinity chromatography.
• Form/Format: Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol
• Sequence Length: 504

• Applicable Applications for anti-TAB1 antibody: Western Blot (WB)
• Application Notes: Western blotting: 1:1000
• Immunogen Type: Recombinant protein
• Immunogen Description: Recombinant fragment, corresponding to amino acids of human TAB1
• Target Name: TAB1
• Preparation and Storage: store at -20 degree C

Testing Data

(1:1000 dilution of this antibody detected TAB1 on 40ug of cell lysates)

Product Categories/Family for anti-TAB1 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 5174703
• NCBI GeneID: 10454
• NCBI Accession #: NP_006107.1
• NCBI GenBank Nucleotide #: NM_006116.2
• UniProt Accession #: Q15750; Q2PP09; Q8IZW2
• Molecular Weight: 49,917 Da
• NCBI Official Full Name: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform alpha
• NCBI Official Synonym Full Names: TGF-beta activated kinase 1/MAP3K7 binding protein 1
• NCBI Official Symbol: TAB1
• NCBI Official Synonym Symbols: 3'-Tab1; MAP3K7IP1
• NCBI Protein Information: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
• UniProt Protein Name: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
• Protein Family: TGF-beta-activated kinase 1 and MAP3K7-binding protein
• UniProt Gene Name: TAB1
• UniProt Synonym Gene Names: MAP3K7IP1; TAK1-binding protein 1
• UniProt Entry Name: TAB1_HUMAN

NCBI Description

The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Uniprot Description

TAB1: May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis. Interacts with XIAP and BIRC7. Interacts with TRAF6 and MAP3K7; during IL-1 signaling. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2. Ubiquitous. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Activator; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 22q13.1

Cellular Component: nucleoplasm; protein complex; cytoplasm; endosome membrane; cytosol

Molecular Function: protein binding; mitogen-activated protein kinase p38 binding; enzyme activator activity; kinase activator activity; protein complex binding; catalytic activity

Biological Process: heart morphogenesis; I-kappaB kinase/NF-kappaB cascade; in utero embryonic development; activation of MAPK activity; MyD88-independent toll-like receptor signaling pathway; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; toll-like receptor 2 signaling pathway; activation of NF-kappaB transcription factor; toll-like receptor 10 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor 5 signaling pathway; transforming growth factor beta receptor signaling pathway; activation of MAPKKK activity; toll-like receptor signaling pathway; innate immune response; JNK cascade; toll-like receptor 9 signaling pathway; toll-like receptor 4 signaling pathway; lung development