Mouse SYK Monoclonal Antibody | anti-SYK antibody

Anti-SYK Antibody (aa5-360) IHC-plus

Cat. Num. AAA249319

• Gene Names: SYK; p72-Syk
• Reactivity: Mouse, Rat, Human
• Applications: Immunohistochemistry, Western Blot, Immunoprecipitation
• Purity: Protein A purified
• Synonyms: SYK; Monoclonal Antibody; Anti-SYK Antibody (aa5-360) IHC-plus; Mouse Monoclonal (IgG1) to Human SYK; Human SYK; p72syk; Spleen tyrosine kinase; Syk protein-tyrosine kinase; Tyrosine-protein kinase SYK; p72-Syk; anti-SYK antibody

• Host: Mouse
• Reactivity: Mouse, Rat, Human
• Clonality: Monoclonal
• Isotype: IgG1
• Purity/Purification: Protein A purified
• Form/Format: PBS, pH 7.4.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 635

• Applicable Applications for anti-SYK antibody: Immunohistochemistry (IHC) Paraffin, Western Blot (WB), Immunoprecipitation (IP)
• Application Notes: IHC-P (10 ug/ml)
• Immunogen: SYK antibody was raised against recombinant fragment corresponding to amino acids 5 - 360 of human Syk.
• Immunogen Description: Recombinant fragment corresponding to amino acids 5 - 360 of human Syk.
• Immunogen Type: Recombinant protein
• Antigen Modification: aa5-360
• Target Species: Human
• Preparation and Storage: Long term: -20 degree C; Short term: 4 degree C; Avoid repeat freeze-thaw cycles

Immunohistochemistry (IHC)

(Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE))

Immunohistochemistry (IHC)

(Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE))

Related Product Information for anti-SYK antibody

SYK Antibody, p72syk Antibody, Spleen tyrosine kinase Antibody, Syk protein-tyrosine kinase Antibody, Tyrosine-protein kinase SYK Antibody, p72-Syk Antibody Description: Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development.

NCBI and Uniprot Product Information

• NCBI GI #: 21361553
• NCBI GeneID: 6850
• NCBI Accession #: NP_003168.2
• NCBI GenBank Nucleotide #: NM_003177.6
• UniProt Accession #: P43405
• Molecular Weight: 69,510 Da
• NCBI Official Full Name: tyrosine-protein kinase SYK isoform Syk(L)
• NCBI Official Synonym Full Names: spleen tyrosine kinase
• NCBI Official Symbol: SYK
• NCBI Official Synonym Symbols: p72-Syk
• NCBI Protein Information: tyrosine-protein kinase SYK
• UniProt Protein Name: Tyrosine-protein kinase SYK
• Protein Family: Tyrosine-protein kinase
• UniProt Gene Name: SYK
• UniProt Entry Name: KSYK_HUMAN

NCBI Description

This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Uniprot Description

Syk: a cytoplasmic tyrosine kinase of the SYK family containing two SH2 domains. Plays a central role in the B cell receptor (BCR) response. An upstream activator of the PI3K, PLCgamma2, and Rac/cdc42 pathways in the BCR response. Required for the sequential events of Fc gamma IIa receptor-mediated phagocytosis. Expression highest in murine spleen, heart, mammary gland and thymus. Two splice variant isoforms have been described.

Protein type: EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); Kinase, protein; Protein kinase, TK; TK group; Syk family

Chromosomal Location of Human Ortholog: 9q22

Cellular Component: B cell receptor complex; cytoplasm; cytosol; extrinsic to internal side of plasma membrane; nucleus; plasma membrane; protein complex; T cell receptor complex

Molecular Function: ATP binding; integrin binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; protein-tyrosine kinase activity; receptor signaling protein tyrosine kinase activity

Biological Process: activation of JNK activity; adaptive immune response; angiogenesis; B cell receptor signaling pathway; beta selection; blood coagulation; blood vessel morphogenesis; cell differentiation; cell proliferation; defense response to bacterium; innate immune response; integrin-mediated signaling pathway; leukocyte activation during immune response; leukocyte adhesion; leukotriene biosynthetic process; lymph vessel development; macrophage activation during immune response; neutrophil activation during immune response; neutrophil chemotaxis; organ morphogenesis; peptidyl-serine phosphorylation; platelet activation; positive regulation of alpha-beta T cell differentiation; positive regulation of alpha-beta T cell proliferation; positive regulation of B cell differentiation; positive regulation of bone resorption; positive regulation of calcium-mediated signaling; positive regulation of cell adhesion mediated by integrin; positive regulation of cytokine secretion; positive regulation of gamma-delta T cell differentiation; positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process; positive regulation of interferon type I production; positive regulation of interleukin-3 biosynthetic process; positive regulation of mast cell degranulation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of receptor internalization; protein amino acid phosphorylation; receptor internalization; regulation of neutrophil degranulation; regulation of phagocytosis; regulation of superoxide release; regulation of transcription factor activity; serotonin secretion by platelet; stimulatory C-type lectin receptor signaling pathway; transcription factor import into nucleus; transmembrane receptor protein tyrosine kinase signaling pathway; viral reproduction