Rabbit anti-Human SULT2B1  Monoclonal Antibody | anti-SULT2B1  antibody

Rabbit anti Human SULT2B1  Monoclonal Antibody

Cat. Num. AAA2544236

• Gene Names: SULT2B1; HSST2
• Reactivity: Human
• Applications: Western Blot, ELISA, Immunoprecipitation
• Synonyms: SULT2B1 ; Monoclonal Antibody; Rabbit anti Human SULT2B1 Monoclonal Antibody; anti-SULT2B1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 350

• Applicable Applications for anti-SULT2B1 antibody: Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
• Application Notes: WB: 10-20 mug/mL; ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human SULT2B1. The detection limit for Human SULT2B1 is approximately 0.00245 ng/well.; IP: 1-4 mug/mg of lysate
• Immunogen: Recombinant Human SULT2B1 Protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-SULT2B1  antibody

Sulfotransferase family cytosolic 2B member 1, also known as Sulfotransferase 2B1, ST2B1, Alcohol sulfotransferase, Hydroxysteroid sulfotransferase 2, SULT2B1 and HSST2, is a cytoplasm protein which belongs to the sulfotransferase 1 family. The human hydroxysteroid sulfotransferase (SULT) family is comprised of two subfamilies, SULT2A1 and SULT2B1. SULT2B1 is expressed highly in placenta, prostate and trachea. A lesser expression of SULT1B1 was observed in the small intestine and lung. SULT2B1 catalyzes the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. SULT2B1 sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol. The two SULT2B1 isoforms, SULT2B1a and SULT2B1b, are encoded by a single gene as a result of alternative transcription initiation and alternative splicing. SULT2B1b catalyzes the sulfonation of 3beta-hydroxysteroid hormones and cholesterol, whereas SULT2B1a preferentially catalyzes pregnenolone sulfonation.

NCBI and Uniprot Product Information

• NCBI GI #: 31563388
• NCBI GeneID: 6820
• NCBI GenBank Nucleotide #: NM_004605.2
• Molecular Weight: 39,599 Da
• NCBI Official Full Name: sulfotransferase family cytosolic 2B member 1 isoform a
• NCBI Official Synonym Full Names: sulfotransferase family 2B member 1
• NCBI Official Symbol: SULT2B1
• NCBI Official Synonym Symbols: HSST2
• NCBI Protein Information: sulfotransferase family cytosolic 2B member 1
• UniProt Protein Name: Sulfotransferase family cytosolic 2B member 1
• UniProt Gene Name: SULT2B1
• UniProt Synonym Gene Names: HSST2; ST2B1; Sulfotransferase 2B1
• UniProt Entry Name: ST2B1_HUMAN

NCBI Description

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene sulfates dehydroepiandrosterone but not 4-nitrophenol, a typical substrate for the phenol and estrogen sulfotransferase subfamilies. Two alternatively spliced variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]

Uniprot Description

SULT2B1: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol. Belongs to the sulfotransferase 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.8.2.2; Energy Metabolism - sulfur; Lipid Metabolism - androgen and estrogen; Transferase

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: cytoplasm; cytosol; intracellular membrane-bound organelle

Molecular Function: alcohol sulfotransferase activity; protein binding; steroid sulfotransferase activity

Biological Process: 3'-phosphoadenosine 5'-phosphosulfate metabolic process; steroid metabolic process