Rabbit anti-Human STK4  Monoclonal Antibody | anti-STK4  antibody

Rabbit anti Human STK4  Monoclonal Antibody

Cat. Num. AAA2544245

• Gene Names: STK4; KRS2; MST1; YSK3
• Reactivity: Human
• Applications: ELISA
• Synonyms: STK4 ; Monoclonal Antibody; Rabbit anti Human STK4 Monoclonal Antibody; anti-STK4 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 487

• Applicable Applications for anti-STK4 antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human STK4. The detection limit for Human STK4 is approximately 0.078 ng/well.
• Immunogen: Recombinant Human STK4/MST1 protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

NCBI and Uniprot Product Information

• NCBI GI #: 5454096
• NCBI GeneID: 6789
• NCBI GenBank Nucleotide #: NM_006282.3
• Molecular Weight: 52,335 Da
• NCBI Official Full Name: serine/threonine-protein kinase 4
• NCBI Official Synonym Full Names: serine/threonine kinase 4
• NCBI Official Symbol: STK4
• NCBI Official Synonym Symbols: KRS2; MST1; YSK3
• NCBI Protein Information: serine/threonine-protein kinase 4
• UniProt Protein Name: Serine/threonine-protein kinase 4
• UniProt Gene Name: STK4
• UniProt Synonym Gene Names: KRS2; MST1; MST-1; MST1/N; MST1/C
• UniProt Entry Name: STK4_HUMAN

NCBI Description

The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]

Uniprot Description

MST1: a protein kinase of the STE20 family. Proteolytically activated by caspase during apoptosis. Activated by apoptotic signals as well as other stress conditions. Full activation requires both phosphorylation and caspase-mediated cleavage. Phosphorylation at serine 327 of Mst1, which is close to the caspase-3 recognition site, inhibits caspase-mediated cleavage.

Protein type: Autophagy; EC 2.7.11.1; Kinase, protein; MST subfamily; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family

Chromosomal Location of Human Ortholog: 20q11.2-q13.2

Cellular Component: cytoplasm; cytosol; nucleus; protein complex

Molecular Function: ATP binding; identical protein binding; magnesium ion binding; protein binding; protein dimerization activity; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity; transcription factor binding

Biological Process: apoptosis; cell morphogenesis; peptidyl-serine phosphorylation; positive regulation of apoptosis; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein amino acid phosphorylation; positive regulation of protein binding; protein amino acid autophosphorylation; protein amino acid phosphorylation; protein stabilization; signal transduction

Disease: T-cell Immunodeficiency, Recurrent Infections, And Autoimmunity With Or Without Cardiac Malformations